Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3442819..3443465 Replicon chromosome
Accession NZ_CP044436
Organism Proteus mirabilis strain C55

Toxin (Protein)


Gene name higB Uniprot ID A0A8E4FP08
Locus tag F7R84_RS16005 Protein ID WP_060555121.1
Coordinates 3442819..3443166 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E4FP64
Locus tag F7R84_RS16010 Protein ID WP_060555120.1
Coordinates 3443166..3443465 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R84_RS15970 3437923..3438216 - 294 WP_049218683.1 YqjK-like family protein -
F7R84_RS15975 3438213..3438574 - 362 Protein_3095 phage holin family protein -
F7R84_RS15980 3438894..3440093 - 1200 WP_049218680.1 lipoprotein-releasing ABC transporter permease subunit LolC -
F7R84_RS15985 3440395..3440796 + 402 WP_049218678.1 PPC domain-containing protein -
F7R84_RS15990 3441213..3441614 - 402 WP_060555124.1 phage holin family protein -
F7R84_RS15995 3441696..3442049 - 354 WP_060555123.1 hypothetical protein -
F7R84_RS16000 3442121..3442369 - 249 WP_060555122.1 DUF883 family protein -
F7R84_RS16005 3442819..3443166 + 348 WP_060555121.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7R84_RS16010 3443166..3443465 + 300 WP_060555120.1 XRE family transcriptional regulator Antitoxin
F7R84_RS16015 3443586..3443774 + 189 WP_060555126.1 DUF5397 family protein -
F7R84_RS16020 3443778..3444056 + 279 WP_060555119.1 virulence factor -
F7R84_RS16025 3444535..3446025 + 1491 WP_060555118.1 YadA-like family protein -
F7R84_RS16030 3446212..3446286 - 75 Protein_3106 IS200/IS605 family transposase -
F7R84_RS16035 3446280..3446387 - 108 Protein_3107 transposase -
F7R84_RS16040 3446437..3446643 - 207 WP_060555117.1 hypothetical protein -
F7R84_RS16045 3446640..3447263 - 624 WP_060555116.1 ParA family protein -
F7R84_RS16050 3447732..3448250 - 519 WP_060555115.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / blaCMY-2 - 3300638..3487444 186806


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13561.55 Da        Isoelectric Point: 8.8337

>T140938 WP_060555121.1 NZ_CP044436:3442819-3443166 [Proteus mirabilis]
MWAVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRLYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFTAHLNTLESK

Download         Length: 348 bp

>T140938 NZ_CP059572:4082802-4083176 [Actinomadura graeca]
GTGCCCTGGGACGTCATCCTCCTCGAACCGGTCGAGAGCTGGTTCCTCAAGCTGTGTGAATCAGAGACGGACACTGCGGC
CTTGATCGAGCAGGCCATCGACAGGCTGGCCGAGGTCGGGCCGACGCTGGGACGGCCGCTGGTCGACACACTGGAACACA
GCGAGCTACGCAACCTCAAGGAGCTGCGGCCCGGCAGCCGAGGACGATCGGAGATCCGCATGCTGTTCGTCTTCGATCCA
GACCGGGCAGCGATCTTCCTAGTGGCCGGAGACAAGGCCGGGCAGTGGTCACGCTGGTACGACGAGGCGATCCCACTGGC
CGAAGCCCGCTACGCCGAGTACCGGGCAGCGAAGGACAAGGAGGGCGGACGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11142.01 Da        Isoelectric Point: 5.8962

>AT140938 WP_060555120.1 NZ_CP044436:3443166-3443465 [Proteus mirabilis]
MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNELKLATLKRYIEAMG
GKLSLDVELPTGKRVAFHL

Download         Length: 300 bp

>AT140938 NZ_CP059572:4083173-4083502 [Actinomadura graeca]
ATGAGCACCGGACGCCGCTGGCAGGACATCAAAGCCGAAGCACACCGCCGCAATCCCGAACTGGCCAACCCCGAACGCCA
GGCCCAGGCACGCACCGAACTAGACGCCTACGTCGCCGGCCACCACCTCAAGGAGCTCCGCAAGGCGGTCGGCAAGACGC
AGGCCGAGGTCGCCCAGATCCTGGGGGTCTCCCAGTCCCGCGTCTCCCAGATCGAAAACGGCAACCTCGAAGCCATGGAG
CTGGAGACCCTCCGCGCCTATGCCACAGCACTCGGCGGACACGTCGACATCACCGTCAGCGTCGGCCCCCACTCCATCAA
GGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References