Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2469092..2469930 Replicon chromosome
Accession NZ_CP044411
Organism Acidithiobacillus sp. 'AMD consortium'

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag F6A13_RS12940 Protein ID WP_126604370.1
Coordinates 2469092..2469604 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag F6A13_RS12945 Protein ID WP_113525968.1
Coordinates 2469601..2469930 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6A13_RS12910 2464214..2465161 + 948 WP_113525973.1 ribose-phosphate pyrophosphokinase -
F6A13_RS12920 2465711..2466874 - 1164 WP_113525972.1 outer membrane beta-barrel protein -
F6A13_RS12925 2467681..2467875 + 195 WP_126604369.1 hypothetical protein -
F6A13_RS12930 2468020..2468163 - 144 Protein_2518 type II toxin-antitoxin system RelB/DinJ family antitoxin -
F6A13_RS12935 2468326..2468952 + 627 WP_172959400.1 trimeric intracellular cation channel family protein -
F6A13_RS12940 2469092..2469604 - 513 WP_126604370.1 type II toxin-antitoxin system YhaV family toxin Toxin
F6A13_RS12945 2469601..2469930 - 330 WP_113525968.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
F6A13_RS12950 2470513..2471154 + 642 WP_192796469.1 hypothetical protein -
F6A13_RS15470 2471398..2471592 + 195 WP_181710098.1 hypothetical protein -
F6A13_RS12955 2471995..2472114 - 120 Protein_2524 IS3 family transposase -
F6A13_RS12965 2472899..2473117 + 219 WP_113525967.1 hypothetical protein -
F6A13_RS12970 2473169..2474206 + 1038 WP_113525966.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pentatricopeptide repeat

(124-143)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 19612.25 Da        Isoelectric Point: 9.7630

>T140923 WP_126604370.1 NZ_CP044411:c2469604-2469092 [Acidithiobacillus sp. 'AMD consortium']
ISAGKPEPLVIHGWTVFAHPLFLAQIEALARQVETLKQKDPAGYVKKNASKRLAAITKLAFDVIPQDPTRPEYRQGGTLG
DDHKHWFRAKFFQQYRLFFRYHAPSKVIVYAWVNDEDSKRAFERSDDAYRVFRKMLESGHPPDDWDQLLAEAQKESQRMQ
ESLARAAAAQ

Download         Length: 513 bp

>T140923 NZ_CP059566:1287265-1287690 [Neisseria sicca]
ATGATTCTGGTGGACACCAATATCATTTCTGAACCGCTCCGCCCCAAACCTGATTCTGCCGTCATCGCTTGGTTGGACAG
ACAACCGGTGGAAACACTATATCTTTCCAGCATTACTGTGGCGGAACTGCGTTTCGGCATAGCCATCCTTCCTGAAGGCG
GAAAAAAACGGCTGTTGTTGGAAAAACTGGAAGAAACAGTATTACCTGTATTTTCAGACCGTATTTTGGATTTTGACATC
GAAGCTGCCGTTGCCTATGCCGAAGTCCGTGCAACAGCGCGGGCAGCAGGATTCACCGTTGCGGCGGCAGACGGCTATAT
TGCGGCCATAGCGCGTTACCACCATATGACGGTAGCTACCCGAGATACGACTCCGTTTACCGCAGCCGGATTAAAAGTCA
TCAACCCGTTTCTAGGTGGTAAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11844.33 Da        Isoelectric Point: 4.5282

>AT140923 WP_113525968.1 NZ_CP044411:c2469930-2469601 [Acidithiobacillus sp. 'AMD consortium']
MAATLEVESTLTDRYQTTVPETVRRALKLGKRDKIHYTIRPSGEVVLTRVQASDGDDPVLGQFLGFLAADITRHPERLQA
VDAGLVQRLQSLVGGVDVDLDAALSADDE

Download         Length: 330 bp

>AT140923 NZ_CP059566:1287035-1287265 [Neisseria sicca]
ATGCCTTCCATTACAGTCAGAAACCTATCCGAAGAGACCCATCGAGCCCTTAAAGCACGCGCATTAGCCGCCGGTCGGAG
TACGGAAGCCGAAATAAGGCTGATACTGGATCAAGCTGCACGTCCCAAACAACGCATCCGTCTTGGTTCACTGTTATCTG
ATATCGGTCGGGAAGCAGGAGGCGTGGATTTGGACATAGAACGGCAAGAGCAAACTGAGGTACGGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References