Detailed information of TA system TA140911

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4405936..4406158
• Replicon: chromosome
• Accession: NZ_CP044410
• Organism: Escherichia coli strain ecMN1F

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: FNW43_RS21345
• Protein ID: WP_000141634.1
• Coordinates: 4405936..4406043 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4406092..4406158 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNW43_RS21320	4401189..4401941	-	753	Protein_4118	cellulose biosynthesis protein BcsQ	-
FNW43_RS21325	4401953..4402141	-	189	WP_001063318.1	YhjR family protein	-
FNW43_RS21330	4402414..4403985	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
FNW43_RS21335	4403982..4404173	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FNW43_RS21340	4404170..4405849	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
FNW43_RS21345	4405936..4406043	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	4406092..4406158	+	67	-	-	Antitoxin
FNW43_RS21355	4406519..4407790	+	1272	WP_001295225.1	transporter	-
FNW43_RS21360	4407820..4408824	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FNW43_RS21365	4408821..4409804	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FNW43_RS21370	4409815..4410717	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T140911 WP_000141634.1 NZ_CP044410:c4406043-4405936 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T140911 NZ_CP059561:c11822-11547 [Conchiformibius steedae]
ATGACAGCAAAATACGAACTTGCGCCAACCAATCAATTTAAGCGGGATATAAAAAAGCGATGGGCAGAACTGTTGGACAG
TGATTGGGTAACGGTGGCCAATTGTTTGATTAACGATGTTGAGCTGCCAATAAAGTACAGAGACCACGAGTTAAAGGGCA
ATCATGCAGGTATTCGTGAATGCCACATTAAACCCGATTTATTGTTGATGTACGAGAAGCAGGAGCAGCAAATTATTCTT
ATCAGGATAGGCACACATTCAGAACTTTTTGGATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT140911 NZ_CP044410:4406092-4406158 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin