Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 3939688..3940415 | Replicon | chromosome |
Accession | NZ_CP044410 | ||
Organism | Escherichia coli strain ecMN1F |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | FNW43_RS19065 | Protein ID | WP_000550189.1 |
Coordinates | 3940101..3940415 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | FNW43_RS19060 | Protein ID | WP_000560266.1 |
Coordinates | 3939688..3940104 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FNW43_RS19050 | 3934848..3937199 | + | 2352 | WP_000695487.1 | alpha-glucosidase | - |
FNW43_RS19055 | 3937625..3939643 | + | 2019 | WP_000121433.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
FNW43_RS19060 | 3939688..3940104 | - | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
FNW43_RS19065 | 3940101..3940415 | - | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
FNW43_RS19070 | 3940699..3941835 | - | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
FNW43_RS19075 | 3941920..3942423 | + | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
FNW43_RS19080 | 3942500..3943192 | + | 693 | WP_000942548.1 | vancomycin high temperature exclusion protein | - |
FNW43_RS19085 | 3943271..3944257 | + | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T140909 WP_000550189.1 NZ_CP044410:c3940415-3940101 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T140909 NZ_CP059560:c424553-424263 [Aromatoleum petrolei]
ATGAAGACCACTCTTACCACCGAGTTCTTCGACGCTTGGTTTGCCTGTCTCCGGGACCCGCAGGCAGCGGCCCGCATCAA
GATGCGGATCGGCCGGGCAGAGTTGGGCGACTTCGGCGACTGTGAATCGGTGGGAGAGGGGGTTTCAGAGATGCGGATCC
ATTATGGGCCGGGCTACCGCGTGTATTTCACCCAGCGCGGCATGGAAGTGGTGATCCTGCTGGCGGGCGGCGACAAGACC
ACCCAAGCCAAGGACATCAAGACCGCCTTGAAGTTGGCACGGGAACTGTAG
ATGAAGACCACTCTTACCACCGAGTTCTTCGACGCTTGGTTTGCCTGTCTCCGGGACCCGCAGGCAGCGGCCCGCATCAA
GATGCGGATCGGCCGGGCAGAGTTGGGCGACTTCGGCGACTGTGAATCGGTGGGAGAGGGGGTTTCAGAGATGCGGATCC
ATTATGGGCCGGGCTACCGCGTGTATTTCACCCAGCGCGGCATGGAAGTGGTGATCCTGCTGGCGGGCGGCGACAAGACC
ACCCAAGCCAAGGACATCAAGACCGCCTTGAAGTTGGCACGGGAACTGTAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT140909 WP_000560266.1 NZ_CP044410:c3940104-3939688 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT140909 NZ_CP059560:c424253-423951 [Aromatoleum petrolei]
ATGGCACTCAAGCTGCGAAAATGGAACACGGCGGAGCACCTCAAGACCGAGGAGGAAATGGCGCTCTACCTCGAGGCTTG
CCTGCAAGAAGCCGGGGACGATGCGGCCTTCATCGCCAAGGCACTGGGCGATATTGCCCGCGCCAAAGGCATGACCCAAC
TGGCCAAGGACACCGGTCTGGGGCGGGAGAGCCTGTACAAGGCCCTTTCCGGCGAGGGCAATCCGAGCTTTGCCACCATC
CTCAAGGTGACGCACGCGTTGGGCCTGCAACTGCACGCGGCACCACGCCACGCGCCGGTGTGA
ATGGCACTCAAGCTGCGAAAATGGAACACGGCGGAGCACCTCAAGACCGAGGAGGAAATGGCGCTCTACCTCGAGGCTTG
CCTGCAAGAAGCCGGGGACGATGCGGCCTTCATCGCCAAGGCACTGGGCGATATTGCCCGCGCCAAAGGCATGACCCAAC
TGGCCAAGGACACCGGTCTGGGGCGGGAGAGCCTGTACAAGGCCCTTTCCGGCGAGGGCAATCCGAGCTTTGCCACCATC
CTCAAGGTGACGCACGCGTTGGGCCTGCAACTGCACGCGGCACCACGCCACGCGCCGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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