Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3873811..3874504 Replicon chromosome
Accession NZ_CP044410
Organism Escherichia coli strain ecMN1F

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FNW43_RS18760 Protein ID WP_000415584.1
Coordinates 3874208..3874504 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FNW43_RS18755 Protein ID WP_000650107.1
Coordinates 3873811..3874206 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW43_RS18745 3869675..3871933 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
FNW43_RS18750 3872071..3873678 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FNW43_RS18755 3873811..3874206 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FNW43_RS18760 3874208..3874504 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FNW43_RS18765 3874709..3875191 - 483 WP_000183505.1 transcriptional regulator -
FNW43_RS18770 3875244..3875636 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FNW43_RS18775 3875788..3876447 + 660 WP_001221495.1 two-component system response regulator QseB -
FNW43_RS18780 3876444..3877793 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FNW43_RS18785 3877839..3878171 - 333 WP_000917684.1 DUF2645 family protein -
FNW43_RS18790 3878490..3879071 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FNW43_RS18795 3879102..3879416 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T140908 WP_000415584.1 NZ_CP044410:c3874504-3874208 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T140908 NZ_CP059560:c424253-423951 [Aromatoleum petrolei]
ATGGCACTCAAGCTGCGAAAATGGAACACGGCGGAGCACCTCAAGACCGAGGAGGAAATGGCGCTCTACCTCGAGGCTTG
CCTGCAAGAAGCCGGGGACGATGCGGCCTTCATCGCCAAGGCACTGGGCGATATTGCCCGCGCCAAAGGCATGACCCAAC
TGGCCAAGGACACCGGTCTGGGGCGGGAGAGCCTGTACAAGGCCCTTTCCGGCGAGGGCAATCCGAGCTTTGCCACCATC
CTCAAGGTGACGCACGCGTTGGGCCTGCAACTGCACGCGGCACCACGCCACGCGCCGGTGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT140908 WP_000650107.1 NZ_CP044410:c3874206-3873811 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT140908 NZ_CP059560:c424553-424263 [Aromatoleum petrolei]
ATGAAGACCACTCTTACCACCGAGTTCTTCGACGCTTGGTTTGCCTGTCTCCGGGACCCGCAGGCAGCGGCCCGCATCAA
GATGCGGATCGGCCGGGCAGAGTTGGGCGACTTCGGCGACTGTGAATCGGTGGGAGAGGGGGTTTCAGAGATGCGGATCC
ATTATGGGCCGGGCTACCGCGTGTATTTCACCCAGCGCGGCATGGAAGTGGTGATCCTGCTGGCGGGCGGCGACAAGACC
ACCCAAGCCAAGGACATCAAGACCGCCTTGAAGTTGGCACGGGAACTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References