Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2795183..2795685 Replicon chromosome
Accession NZ_CP044410
Organism Escherichia coli strain ecMN1F

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FNW43_RS13730 Protein ID WP_000767829.1
Coordinates 2795183..2795437 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FNW43_RS13735 Protein ID WP_001259255.1
Coordinates 2795434..2795685 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW43_RS13700 2790198..2790425 - 228 WP_000234896.1 sulfurtransferase TusA -
FNW43_RS13705 2790439..2791497 - 1059 WP_000492339.1 transport protein YeeE -
FNW43_RS13710 2791676..2793034 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FNW43_RS13715 2793024..2793086 - 63 WP_010723108.1 membrane protein YoeI -
FNW43_RS13720 2793301..2794230 - 930 WP_000803351.1 LysR family transcriptional regulator -
FNW43_RS13725 2794276..2795100 - 825 WP_000754737.1 SDR family oxidoreductase -
FNW43_RS13730 2795183..2795437 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FNW43_RS13735 2795434..2795685 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FNW43_RS13740 2795968..2796018 + 51 WP_001364200.1 his operon leader peptide -
FNW43_RS13745 2796164..2797063 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
FNW43_RS13750 2797069..2798373 + 1305 WP_000009594.1 histidinol dehydrogenase -
FNW43_RS13755 2798370..2799440 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
FNW43_RS13760 2799440..2800507 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T140903 WP_000767829.1 NZ_CP044410:c2795437-2795183 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T140903 NZ_CP059556:c6196260-6195928 [Saccharopolyspora gregorii]
GTGGCGTTCACCGTCGTCTACGACGCCGATGTCCTGTACCCGAGCACGCTGCGGGACTTGCTGATCAGGCTCGCGCAGGC
GGGGCTCGTGCAGGCCAAGTGGACGGATCAGATCCTGGACGAGACGTTCCGGAACACGCAGCGGAACCGCCCGGACCTCG
ATCCGCGGAACCTCGATCGCACGCGCGAGCTGATGCTGAGGGCGGTGCGGGACTGCCTGGTCAAAGGCTACGAGCCGCTG
ATCGACGTGCTCGATCTGCCGGATCCGGACGACCGGCACGTGTTGGGGCGCGACGGGCTGGTGGAATCGACGGCCGCGTT
GCAGGCGATGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT140903 WP_001259255.1 NZ_CP044410:c2795685-2795434 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT140903 NZ_CP059556:c6196721-6196263 [Saccharopolyspora gregorii]
ATGAACTCGCTCGCGCTCGACCCGATCCAACCTGACGGGGCCGATGCGGCCGTCGCTGACGAAGCGCTGCAACGGATCAA
GGGCTACCTCGGCAGGCATCAAGATCAGCGCCGCATTCCGCTCGTCGTGGAGGACGACGGGTGCGAAACGTTGGTCGTCC
CCCGTGGCGCTGTCGAACTGCTGGCCCGCGTGCTCGCCCACATGGCAGCGGGTACCGGCGTGTCCGTCGTGCCGTCCCAT
GCCGAGCTGACCACTCAGCAGGCGGCGGAGATGCTCAACGTGTCGCGTCCGTTCCTGGTCGGGCTGCTGGAAGCCGGGGA
GATCGACCATCGGAAGGTCGGCACGCATCGCCGAGTCCGGGCTGAGTCGGTCCTCGCCTACTTGCGCGAGGACGACAAGC
GTCGCCGCGAGGCCGCCGACGAGCTGACCCGGCTCACCCAGGAGATGGGACTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References