Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4223994..4224505 Replicon chromosome
Accession NZ_CP044407
Organism Actinomadura sp. WMMB 499 strain WMMB499

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F7P10_RS18520 Protein ID WP_151010481.1
Coordinates 4224251..4224505 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F7P10_RS18515 Protein ID WP_151010480.1
Coordinates 4223994..4224254 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7P10_RS18500 4219679..4221838 - 2160 WP_151010478.1 MMPL family transporter -
F7P10_RS18505 4222070..4223242 + 1173 WP_151018135.1 sensor histidine kinase -
F7P10_RS18510 4223239..4223916 + 678 WP_151010479.1 response regulator transcription factor -
F7P10_RS18515 4223994..4224254 + 261 WP_151010480.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F7P10_RS18520 4224251..4224505 + 255 WP_151010481.1 Txe/YoeB family addiction module toxin Toxin
F7P10_RS18525 4224557..4224790 + 234 WP_151010482.1 hypothetical protein -
F7P10_RS18530 4224800..4225423 - 624 WP_176611533.1 TetR/AcrR family transcriptional regulator -
F7P10_RS18535 4225637..4226854 + 1218 WP_151018136.1 cytochrome P450 -
F7P10_RS18540 4226851..4227693 + 843 WP_151010484.1 DUF2236 domain-containing protein -
F7P10_RS18545 4227690..4229285 + 1596 WP_151010485.1 AMP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10012.37 Da        Isoelectric Point: 8.4416

>T140869 WP_151010481.1 NZ_CP044407:4224251-4224505 [Actinomadura sp. WMMB 499]
VKLSFTPEGWEDYTSWLSTDRQTLKRINRLIDDALRDPYEGIGKPEPLKHALQGAWSRRITEEHRLVYLPRGDELIILQA
RYRY

Download         Length: 255 bp

>T140869 NZ_CP059488:1644699-1644962 [Acidithiobacillus ferrivorans]
ATGATTGAGATTGACGACAAGGTTAAGAAGGACTTGGCCGCGCTGGACAAGGCCATTGTCAAGCGCATCACGACGTTTCT
GCGCGAGCGTATTGCCCAGCTCGACGACCCGCGCAGCATTGGCGAAGCCCTCAAAGGTTCCAAGCTGGGAGCCTTCTGGA
AGTACCGCGTTGGCGACTATCGAATCATTGCCAGCATCGAGGACAGTGCTTTGCGTATCCTCGTTATTCGCATCGGCAAT
CGCAAGGAGGTTTACCGTCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9762.83 Da        Isoelectric Point: 4.5562

>AT140869 WP_151010480.1 NZ_CP044407:4223994-4224254 [Actinomadura sp. WMMB 499]
MSITASEARRRLFPLIDEVNDDGAPVEIVAKNNRAYLVSAAEYEALEETAHLLRSPANTRRLMTAYQHALEGRHEIRDTI
DPDEEQ

Download         Length: 261 bp

>AT140869 NZ_CP059488:1644482-1644706 [Acidithiobacillus ferrivorans]
ATGCTTGCCATCCGACTACCCGCCGAAGTGGAAACCCGCCTTGAAGCACTGGCGCAGGCTACCGGGCGCACCAAGACCTT
CTATGCCCGCGAAGCCATCCTTGAGCACTTGGACGACCTCGAAGATTTGTACCTTGCAGAGCAACGCCTGATCGACATTC
GAGCAGGACGCAGCCGAACGTACACGCTGGACGAAGTGGAGCGCGATCTTGGCTTGGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References