Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4343342..4344035 Replicon chromosome
Accession NZ_CP044403
Organism Escherichia coli strain NMBU-W10C18

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag F7O57_RS21320 Protein ID WP_000415584.1
Coordinates 4343739..4344035 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag F7O57_RS21315 Protein ID WP_000650107.1
Coordinates 4343342..4343737 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7O57_RS21305 4339206..4341464 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
F7O57_RS21310 4341602..4343209 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
F7O57_RS21315 4343342..4343737 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
F7O57_RS21320 4343739..4344035 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
F7O57_RS21325 4344240..4344722 - 483 WP_000183505.1 transcriptional regulator -
F7O57_RS21330 4344775..4345167 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
F7O57_RS21335 4345319..4345978 + 660 WP_001221493.1 two-component system response regulator QseB -
F7O57_RS21340 4345975..4347324 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
F7O57_RS21345 4347370..4347702 - 333 WP_023149630.1 DUF2645 family protein -
F7O57_RS21350 4348021..4348602 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
F7O57_RS21355 4348633..4348947 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T140858 WP_000415584.1 NZ_CP044403:c4344035-4343739 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T140858 NZ_CP059485:c1368-1060 [Enterobacter kobei]
ATGCAGTTCATGGTTTACCGCAATAACAGCAACAACCGGGCTTATCCCTATCTGCTCGATGTACAGAGCGATATTATCGA
CGAACTGAATACCCGCCTGGTGATCCCGCTGTTTCTGCTGGATGAAGTGAATGGACGGCCCGCCCGCCGCCTGACCCCGG
TGCTGAATGTGGACGGTGAGGATTTTCTGGTCATGACACATGAAATGGCCAGCGTTCGCCAGTCACAGCTCGGGGAAGAG
GTGGTGAGCGTCCGGGAGCACCGGCAGGCCATCAAGAATGCGCTGGATTTTCTGCTCGACGGTTTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT140858 WP_000650107.1 NZ_CP044403:c4343737-4343342 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT140858 NZ_CP059485:c1607-1368 [Enterobacter kobei]
ATGCCCGTATCAGCGATGCGCCATAAAAAAACCGTCAGTGTGACAATCGAGCCTGCGCTTTTGCATCAGGCCCGCGAAGC
CGGGATTAATCTGTCTGCCACGCTCACCACCGCCCTGAAACATCAGATCCGCGAGTCAGAAGCGGAGCGCTGGAAACGCG
CCAACCGCAAGGCAATCCAGGAGCTCAACCGTATTACGGACGAGCACGGCTTACTCTCTGACGATCACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References