Detailed information of TA system TA140816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 2081895..2082528
• Replicon: chromosome
• Accession: NZ_CP044399
• Organism: Moritella marina ATCC 15381 strain MP-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5J6WIZ9
• Locus tag: FR932_RS09380
• Protein ID: WP_019441780.1
• Coordinates: 2081895..2082227 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FR932_RS09385
• Protein ID: WP_019441779.1
• Coordinates: 2082214..2082528 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR932_RS09365	2077400..2078920	+	1521	WP_019441783.1	aldehyde dehydrogenase	-
FR932_RS09370	2079256..2081496	+	2241	WP_019441782.1	mechanosensitive ion channel	-
FR932_RS09375	2081480..2081674	+	195	Protein_1807	aldehyde dehydrogenase family protein	-
FR932_RS09380	2081895..2082227	+	333	WP_019441780.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FR932_RS09385	2082214..2082528	+	315	WP_019441779.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FR932_RS09390	2082656..2082837	+	182	Protein_1810	aldehyde dehydrogenase family protein	-
FR932_RS09395	2082978..2084429	-	1452	WP_019441777.1	hypothetical protein	-
FR932_RS09400	2084798..2085067	+	270	WP_019441776.1	DUF1778 domain-containing protein	-
FR932_RS09405	2085236..2085790	+	555	WP_019441775.1	pyrimidine dimer DNA glycosylase/endonuclease V	-
FR932_RS09410	2085971..2086675	+	705	WP_019441774.1	histidine utilization repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (8-103)

Antitoxin

• Antitoxin MqsA/HigA-2 (19-101)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12955.89 Da
• Isoelectric Point: 10.0021

>T140816 WP_019441780.1 NZ_CP044399:2081895-2082227 [Moritella marina ATCC 15381]
MKCIFVESKIFEKYRDEHLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKVRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKSEMSDLTADQKKQLKSFMEVWRNEQS

Nucleotide

• Length: 333 bp

>T140816 NZ_CP059467:3700302-3700730 [Aromatoleum bremense]
ATGCGTGCGCTGCTGGACGTGAATGTCCTCATCGCGCTGCTCGACGGCAGCCACGTGCACCACGCACGCGCAAGCCGGTG
GCTCGCAGGTGAAATCGAGCATGGCTGGGCATCGTGTCCGCTGACCCAAAACGGTTGCCTGCGCATCATGGCTCAACCTG
CCTACCCGCAGGCTTTGCCACTGGGCGCCGTTGCAAGCCGTCTGGCCCAGGCCACCGCACACCCGGCGCACCAGTTCATC
GCCGACGACTACAGTCTGCTCGATGGCGCACAGATCACCTGGCAAAACCTGCTCGGTCACCGGCAGATTACCGACACTTA
TCTGCTCGGCCTCGCCGTGCGGCACGACTGCCGCTTCGTCAGCTTCGATGCACGGATCAACCCCGGCATCGTCACCGGCG
CACAGCCCAAACACTGGTGCACGCTTTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11714.21 Da
• Isoelectric Point: 6.7602

>AT140816 WP_019441779.1 NZ_CP044399:2082214-2082528 [Moritella marina ATCC 15381]
MSNRDLFTELSSALVEAKEHSEGKLTLKTHQVNDVSELNISPNEIVHIREKFNMSRGVFASLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLTHIAEL

Nucleotide

• Length: 315 bp

>AT140816 NZ_CP059467:3700057-3700302 [Aromatoleum bremense]
ATGCGCACTACGATCGACATCGAAAGCGACGTCCTTGCCGCCGCGAAGGAAATCGCACGCCAGCAACACACCAGTGTCGG
CAAAGTCATCTCCCGGCTCGTTCGCCAAAGCCTGACCGGTGCCGCTGCCCCGCAAACCGTTGCCCACCAGACTCCCGCAG
TCCCCGGCTTCGAGCCCTTTCCGGCCCGTGACGTCATCGTGACCAACGAGCTCATCGACCGTCTGCGCGACGCCGAGGGA
ATCTGA

Structures

Toxin

• AlphaFold DB: A0A5J6WIZ9