140801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1681563..1682077 Replicon chromosome
Accession NZ_CP044354
Organism Limosilactobacillus fermentum strain 2760

Toxin (Protein)


Gene name yoeB Uniprot ID A0A829M010
Locus tag F4U91_RS08565 Protein ID WP_023465988.1
Coordinates 1681563..1681826 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag F4U91_RS08570 Protein ID WP_003684069.1
Coordinates 1681823..1682077 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4U91_RS08545 1678043..1678459 - 417 Protein_1627 IS256 family transposase -
F4U91_RS08550 1678511..1679395 - 885 Protein_1628 IS30 family transposase -
F4U91_RS08555 1679400..1679525 + 126 Protein_1629 transposase -
F4U91_RS08560 1680032..1681153 + 1122 WP_023465987.1 PTS sugar transporter subunit IIC -
F4U91_RS08565 1681563..1681826 - 264 WP_023465988.1 Txe/YoeB family addiction module toxin Toxin
F4U91_RS08570 1681823..1682077 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F4U91_RS08575 1682463..1683833 - 1371 WP_003684065.1 FAD-dependent oxidoreductase -
F4U91_RS08580 1683961..1685148 - 1188 WP_151130393.1 IS256 family transposase -
F4U91_RS08585 1685425..1685856 + 432 Protein_1635 IS30 family transposase -
F4U91_RS08590 1685941..1686228 + 288 WP_003688751.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1664308..1701968 37660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10267.91 Da        Isoelectric Point: 10.0702

>T140801 WP_023465988.1 NZ_CP044354:c1681826-1681563 [Limosilactobacillus fermentum]
MSYAIELKRSANKELKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

>T140801 NZ_CP059446:23398-24054 [Campylobacter fetus]
ATGAAAGAAAGCAATGAAGAACTTTTTAAAAAATTAATTGCAGACAATAAACTTGGCATAAAAGATGAAAAATTATTTGA
TAAAGAATCAAGAAAATATACTCTAGTAAGAACTAAAGAAATAATTAAAACGCCTATTAAAGGCAATTTTGATTATCAGC
ATTTGAAAAATATACATAAATATATTTTTCAAGATGTATTTCACTGGGCTGGAAAAGATAGAATGGAAGTAGGTTTGCAT
GGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCCTGGAAAAGATTTAAATGCAACCGCTCAACA
AATTTTTACTTGGCTTAAAGAAGACAATTACTTAAAAAATTCAAAAGATCTTAACGATTTTGCAAAGAACTTAGCCGAAT
TTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAATGAATTGACT
AAAAATGTAGGTTATAAACTTGATTTAAATTTAATACCAAAAAATAAAATGATAATGGCATCTGTAGAAGCTTCACAATT
GAAATTAGGAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGCTTTAAGCAAAATTTAGAAAAAGAAAATACATTAG
GATTATCCTTATGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT140801 WP_003684069.1 NZ_CP044354:c1682077-1681823 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT140801 NZ_CP059446:23166-23414 [Campylobacter fetus]
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGTAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACACGCTATCGAAGATATTTTTGCAAATGAAGAAGATATTATTATGCTAG
TAAAAATGAGCACATATAATCTAAGTAGTGATGAGATACTAGCAGAATACAAAGAAAAGGGATTTGTAGAATATGAAAGA
AAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829M010

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References