Detailed information of TA system TA140791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 457238..457805
• Replicon: chromosome
• Accession: NZ_CP044352
• Organism: Xylella fastidiosa strain ATCC 35879

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q87EE4
• Locus tag: F7G16_RS01925
• Protein ID: WP_004090695.1
• Coordinates: 457238..457519 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: F7G16_RS01930
• Protein ID: WP_004085172.1
• Coordinates: 457530..457805 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7G16_RS01900	453661..454380	-	720	Protein_347	phage late control D family protein	-
F7G16_RS01905	454280..455251	-	972	WP_159241593.1	hypothetical protein	-
F7G16_RS01910	455259..455816	-	558	WP_011097610.1	phage tail protein I	-
F7G16_RS01915	455809..456702	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
F7G16_RS01920	456702..457040	-	339	WP_004090694.1	GPW/gp25 family protein	-
F7G16_RS01925	457238..457519	+	282	WP_004090695.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F7G16_RS01930	457530..457805	+	276	WP_004085172.1	HigA family addiction module antidote protein	Antitoxin
F7G16_RS01935	457893..458195	+	303	WP_004090696.1	type II toxin-antitoxin system MqsR family toxin	-
F7G16_RS01940	458198..458599	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	-
F7G16_RS01945	458668..459255	-	588	WP_011097612.1	phage baseplate assembly protein V	-
F7G16_RS01950	459252..459794	-	543	WP_011097613.1	hypothetical protein	-
F7G16_RS01955	459770..460291	-	522	WP_011097614.1	hypothetical protein	-
F7G16_RS01960	460288..460611	-	324	WP_011097935.1	hypothetical protein	-
F7G16_RS01965	460589..460870	-	282	WP_159241635.1	hypothetical protein	-
F7G16_RS01970	460888..462762	-	1875	WP_038232803.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	444602..468667	24065

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10639.21 Da
• Isoelectric Point: 10.0980

>T140791 WP_004090695.1 NZ_CP044352:457238-457519 [Xylella fastidiosa]
MIKSFRHKGIQQFFLKGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Nucleotide

• Length: 282 bp

>T140791 NZ_CP059433:9818-10504 [Campylobacter fetus]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTTA
ATCCAATTAAAGGCAATTTTGACTACCAACATTTAAAAGATATACATAAAGCACTTTTTAAAGATGTTTATACTTGGGCT
GGAAAAGATAGAATGGAAGTAGGTTTGCATGGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCC
TGGAAAAGATTTAAATGCAACCGCTCAACAAATTTTTACTTGGCTTAAAGAAGACAATTACTTAACAAATTCAAAAGATC
TTAACGATTTTGCAAAGAACTTAGCCGAATTTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAAT
GATAATGGCATCTGTAGAAGCTTCACAATTGAAATTAGGAAAACTTGAAGCCATAATAAAAACAAATCTAAAAAGCTTTA
AGCAAAATTTAGAAAAAGAAAATACATTAGGCTTATCCCTATGTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10072.68 Da
• Isoelectric Point: 10.2184

>AT140791 WP_004085172.1 NZ_CP044352:457530-457805 [Xylella fastidiosa]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Nucleotide

• Length: 276 bp

>AT140791 NZ_CP059433:9589-9825 [Campylobacter fetus]
ATGACATATCCAGAAGTACATAGCCTAGAAGAGAGTTTAGCAATACTTAAAAAATACAAAGATGATTTAACTAAAGAGCA
ATACGATGGAATTAAATCTATAATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAGAGACATTATTGATATGA
TAAAAATTGCAAAAAATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGAGTAAATGATTGA

Structures

Toxin

• AlphaFold DB: Q87EE4