Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 548947..549815 | Replicon | chromosome |
| Accession | NZ_CP044345 | ||
| Organism | Mycobacterium tuberculosis strain L | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | F6W99_RS02590 | Protein ID | WP_010886136.1 |
| Coordinates | 548947..549324 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | F6W99_RS02595 | Protein ID | WP_003913306.1 |
| Coordinates | 549366..549815 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F6W99_RS02540 | 544736..545188 | - | 453 | WP_003899095.1 | lipoprotein | - |
| F6W99_RS02545 | 545252..545653 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| F6W99_RS02550 | 545646..545828 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| F6W99_RS02555 | 545942..546292 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| F6W99_RS02560 | 546303..547205 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| F6W99_RS02565 | 547226..547417 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| F6W99_RS02570 | 547418..547714 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| F6W99_RS02575 | 547954..548169 | + | 216 | WP_003409878.1 | antitoxin | - |
| F6W99_RS02580 | 548166..548477 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| F6W99_RS21590 | 548451..548972 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| F6W99_RS02590 | 548947..549324 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| F6W99_RS02595 | 549366..549815 | + | 450 | WP_003913306.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| F6W99_RS02600 | 549812..550357 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| F6W99_RS02605 | 550246..550861 | - | 616 | Protein_501 | hypothetical protein | - |
| F6W99_RS02610 | 550911..551207 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| F6W99_RS02615 | 551204..551455 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| F6W99_RS02620 | 551442..551936 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| F6W99_RS02625 | 552096..552503 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| F6W99_RS02630 | 552507..552779 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| F6W99_RS02635 | 552812..554032 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T140734 WP_010886136.1 NZ_CP044345:548947-549324 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T140734 NZ_CP059391:c1795879-1795526 [Klebsiella africana]
GTGTGGACGATTAAAACAACGGATATGTTTGATCGCTGGTTTACCTCGCTCAATGATATCGATCGGGCCAGCGTGCTGGC
AGCGCTGTTGGTCTTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGATCAGAGGTTCCCGCTACAGCA
ACATGAAAGAGTTGCGTGTTCAGAGCCGGGGCGACCCAATACGGGCGTTTTTTCCTTTTGACCCAGCCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGGTTTTACCATGAGATGCTCGCGGTCGCAGATCGGGAATTCAC
GAACTGGCTTAACAGATTGAAAGAGAAGGAGTAA
GTGTGGACGATTAAAACAACGGATATGTTTGATCGCTGGTTTACCTCGCTCAATGATATCGATCGGGCCAGCGTGCTGGC
AGCGCTGTTGGTCTTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGATCAGAGGTTCCCGCTACAGCA
ACATGAAAGAGTTGCGTGTTCAGAGCCGGGGCGACCCAATACGGGCGTTTTTTCCTTTTGACCCAGCCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGGTTTTACCATGAGATGCTCGCGGTCGCAGATCGGGAATTCAC
GAACTGGCTTAACAGATTGAAAGAGAAGGAGTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16776.16 Da Isoelectric Point: 8.0771
>AT140734 WP_003913306.1 NZ_CP044345:549366-549815 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
Download Length: 450 bp
>AT140734 NZ_CP059391:c1795521-1795219 [Klebsiella africana]
ATGGGCAGAACGCTGGAACAGCTTCTTATAGATGAAAAACCGGATGTCGTTGCCGAAGCTCAGGCTATTGCTAAGGATAT
CCTGCTTAATATTCATCTTGCCGAACTACGTGAGAAGGTGCAGAAGACCCAGGTAGAAATGGCTCAGGATTTAGGCATAA
AACAGCCTACCGTTGCAGGAATGGAAAAACCGGGCCGCGACCTGAAGCTCTCTACCCTTAAGCGTTATGTTGAAGCGGCG
GGTGGTAAGCTGCGGCTTGATGTTGAGCTCCCGGACGGGTCGCACTATGAGTTTGTTTTGTAG
ATGGGCAGAACGCTGGAACAGCTTCTTATAGATGAAAAACCGGATGTCGTTGCCGAAGCTCAGGCTATTGCTAAGGATAT
CCTGCTTAATATTCATCTTGCCGAACTACGTGAGAAGGTGCAGAAGACCCAGGTAGAAATGGCTCAGGATTTAGGCATAA
AACAGCCTACCGTTGCAGGAATGGAAAAACCGGGCCGCGACCTGAAGCTCTCTACCCTTAAGCGTTATGTTGAAGCGGCG
GGTGGTAAGCTGCGGCTTGATGTTGAGCTCCCGGACGGGTCGCACTATGAGTTTGTTTTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|