Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2958075..2958577 Replicon chromosome
Accession NZ_CP044335
Organism Enterobacter hormaechei strain AKB48

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag D6T76_RS13865 Protein ID WP_032103793.1
Coordinates 2958323..2958577 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag D6T76_RS13860 Protein ID WP_032103791.1
Coordinates 2958075..2958326 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6T76_RS13835 2953254..2953448 + 195 WP_169723583.1 hypothetical protein -
D6T76_RS13840 2953472..2953657 + 186 WP_151406470.1 hypothetical protein -
D6T76_RS13845 2953725..2955821 + 2097 WP_169723584.1 peptidase domain-containing ABC transporter -
D6T76_RS13850 2955818..2956567 + 750 WP_169723585.1 hypothetical protein -
D6T76_RS13855 2956574..2957824 + 1251 WP_169723586.1 HlyD family efflux transporter periplasmic adaptor subunit -
D6T76_RS13860 2958075..2958326 + 252 WP_032103791.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D6T76_RS13865 2958323..2958577 + 255 WP_032103793.1 Txe/YoeB family addiction module toxin Toxin
D6T76_RS13870 2958653..2958970 + 318 WP_169723587.1 DUF1493 family protein -
D6T76_RS13875 2958995..2959312 - 318 WP_169723588.1 type VI secretion system tube protein Hcp -
D6T76_RS13880 2959313..2960401 - 1089 WP_169723589.1 AAA family ATPase -
D6T76_RS13885 2960549..2961508 - 960 WP_169723590.1 DUF523 and DUF1722 domain-containing protein -
D6T76_RS13890 2961611..2962021 - 411 WP_017383647.1 hydroxyisourate hydrolase -
D6T76_RS13895 2962121..2962846 - 726 WP_169723591.1 MerR family transcriptional regulator -
D6T76_RS13900 2962964..2963488 + 525 WP_032652079.1 lipocalin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10089.65 Da        Isoelectric Point: 7.8740

>T140722 WP_032103793.1 NZ_CP044335:2958323-2958577 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVKKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Download         Length: 255 bp

>T140722 NZ_CP059386:c1447872-1447609 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9313.55 Da        Isoelectric Point: 4.7854

>AT140722 WP_032103791.1 NZ_CP044335:2958075-2958326 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGGGKERD
IIE

Download         Length: 252 bp

>AT140722 NZ_CP059386:c1448122-1447859 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References