Detailed information of TA system TA140703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2854529..2855118
• Replicon: chromosome
• Accession: NZ_CP044334
• Organism: Xanthomonas arboricola pv. pruni strain 15-088

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2S7AZR2
• Locus tag: F6Y24_RS12655
• Protein ID: WP_039429225.1
• Coordinates: 2854529..2854810 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: F6Y24_RS12660
• Protein ID: WP_006449989.1
• Coordinates: 2854828..2855118 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y24_RS12650	2852263..2854389	+	2127	WP_043087609.1	exodeoxyribonuclease V subunit alpha	-
F6Y24_RS12655	2854529..2854810	+	282	WP_039429225.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F6Y24_RS12660	2854828..2855118	+	291	WP_006449989.1	HigA family addiction module antidote protein	Antitoxin
F6Y24_RS12670	2855661..2855993	-	333	WP_039513672.1	lipoprotein	-
F6Y24_RS12675	2856167..2858065	-	1899	WP_126750750.1	hypothetical protein	-
F6Y24_RS12680	2858140..2858976	-	837	WP_081327584.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11046.72 Da
• Isoelectric Point: 9.7972

>T140703 WP_039429225.1 NZ_CP044334:2854529-2854810 [Xanthomonas arboricola pv. pruni]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T140703 NZ_CP059348:3972006-3972266 [Providencia rettgeri]
ATGAGTAGACTTCTAACATGGACGGATCAAGCTTGGGATGATTATCTATACTGGCAAAGCCAAGATAAAAAGACATTAAA
GCGGATCAATAAACTCATTGAAGACACAAAAAGAACGCCATTCAGCGGTATAGGTAAACCAGAGCCACTAAAAGAAAACT
TAGCTGGCTTCTGGTCTCGTAGAATAGATGAAACGAATAGGCTAGTTTATGCAATCGAAAATACCGCACTAGTCATCATT
GCCTGTCGCTATCATTACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10540.20 Da
• Isoelectric Point: 6.4664

>AT140703 WP_006449989.1 NZ_CP044334:2854828-2855118 [Xanthomonas arboricola pv. pruni]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT140703 NZ_CP059348:3971759-3972013 [Providencia rettgeri]
ATGAAAACCATTTCCTTTAGTGATGCGAGAAGCAATTTGAAAGCCGTGCTTGATAGAGTTGTTGATGATATGGATACGAC
GATTATAACCCGCCGTGATTCTGAAGCGGCTGTAGTTATGTCCTTGGAATACTACAATAGTTTAATGGAAACCATCTATC
TATTGCGCTCTCCTGCAAATGCAGAGCATCTCAACAAGTCCATCGAGCAATTTAAAGCGGGTAAGATTTCAGAGAGAAAG
CTAATCAATGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2S7AZR2