140690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32639..33158 Replicon plasmid p15-307-1_04
Accession NZ_CP044320
Organism Enterococcus faecium strain 15-307-1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag CWC51_RS16025 Protein ID WP_000588503.1
Coordinates 32901..33158 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag CWC51_RS16020 Protein ID WP_000388479.1
Coordinates 32639..32908 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC51_RS15985 28210..28626 - 417 WP_001232859.1 hypothetical protein -
CWC51_RS15990 28629..28913 - 285 WP_000353844.1 hypothetical protein -
CWC51_RS15995 29258..29503 + 246 WP_002311817.1 hypothetical protein -
CWC51_RS16000 29805..29900 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
CWC51_RS16005 30626..31306 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
CWC51_RS16010 31382..31948 + 567 Protein_37 hypothetical protein -
CWC51_RS16015 32329..32508 + 180 WP_001120991.1 hypothetical protein -
CWC51_RS16020 32639..32908 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWC51_RS16025 32901..33158 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
CWC51_RS16030 33796..34383 + 588 Protein_41 hypothetical protein -
CWC51_RS16035 34538..35857 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
CWC51_RS16040 36061..36303 + 243 Protein_43 hypothetical protein -
CWC51_RS16045 36468..37082 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..41619 41619
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..35857 34200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T140690 WP_000588503.1 NZ_CP044320:32901-33158 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T140690 NZ_CP059347:2434657-2435115 [Providencia rettgeri]
ATGATCCTATATCGGTTGGTTAAATCCATTTTTGCTCACGATGCATGGTCGGGCCAAGGGGCTATGCTCTATGGTGGGCG
TTGGAATCATAAAGGGACTCCCGCTGTTTATACATCGACGAGTATTTCATTAGCAACCCTTGAAATACTCGTACACATCA
ATCAAGACATACTATTAAACCAGTTCAGTTTACTATCCATAGATATCAATGATAAGTACGTAATGAAATTGTCGTTAGAC
CACCTTCCAACGGATTGGCAGCAAGACCCAGCGTCAACCTCTACAATGGATATTGGCACTACATGGCTTAATAACCAAGA
TAGCTTAGTATTGTTAATTCCCTCTTGTATTATTCCCTATGAATACAACGCAATAATCAACCCGTTGCATCCGCAATTTC
AAAAAGCCATACGGACGGTTAAACCACTGGATTTTAGCGTTGATCCACGCTTAGCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT140690 WP_000388479.1 NZ_CP044320:32639-32908 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT140690 NZ_CP059347:2434199-2434660 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACGCCGCTTCAACCCGCAGCTTCTGCTTCTAAGCCACTATGGCGCCATGTCGGGTTACC
CGCTGAAAGGGGTATTGAATTAACCCATTATTTACGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAGTGGT
CAGGGGTGAGCAAAACAGAACTATTGCGGATATCTGGTATCAATGAACGCAATATCGCTCGTCGCAAAAATGCTGGCCAG
CCCCTAAATGCTGATGAAAGTGAACGAATTGCACGTCTAGTAAGGGTATTTGATGCCGCAGTGCGTTTATTTAATGGTGA
TAAACACGCAGCAAGTGATTGGCTCAATCACCCAGTGAAAGGCTTGGGTCATTTACGCCCTATTGAGCTTATCGCAACAG
AAAGCGGAGCCATTGAAGTGATTGATTTAATTGGCCGTATTGAACATGGTGTATTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References