Detailed information of TA system TA140685

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1912712..1913011
• Replicon: chromosome
• Accession: NZ_CP044316
• Organism: Enterococcus faecium strain 15-307-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CWC51_RS09365
• Protein ID: WP_085811512.1
• Coordinates: 1912778..1913011 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1912712..1912798 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWC51_RS09345	1908551..1908745	-	195	WP_085811488.1	hypothetical protein	-
CWC51_RS09350	1908745..1911309	-	2565	WP_085811487.1	trse protein	-
CWC51_RS09355	1911525..1911704	-	180	WP_085811486.1	putative holin-like toxin	-
CWC51_RS09360	1911745..1912440	-	696	WP_085811485.1	hypothetical protein	-
-	1912712..1912798	+	87	-	-	Antitoxin
CWC51_RS09365	1912778..1913011	-	234	WP_085811512.1	putative holin-like toxin	Toxin
CWC51_RS09370	1913001..1913393	-	393	WP_085811484.1	hypothetical protein	-
CWC51_RS09375	1913405..1915534	-	2130	WP_085811483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (44-77)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8599.39 Da
• Isoelectric Point: 10.4853

>T140685 WP_085811512.1 NZ_CP044316:c1913011-1912778 [Enterococcus faecium]
ITCNLGKCLWYNNRTVKFVTVAIFWKVVVLMEVSVHSLERRSLLSVAEALGLMISFGSLIATIIFGILTAVKNDKKK

Nucleotide

• Length: 234 bp

>T140685 NZ_CP059346:c2659519-2659109 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACCCAGCTTTTTTCAACCAGCCTCCATGTGGGGGCGGGTAT
CATTTTGCTTGTTGCACCATGGGAACCTGGTAACTCGATGATTTGGCTTCCATTATTGGTTATCTTAGTGGCGAGCTGGG
CAAAAAGTCAAAAGAACATTAGCAAAGTGAAAGGCGTTGCTGTACTGGTGAATGGCAATAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATAATCAAAGCACCATGGTGTAGCCGTTGTGGTATTTTATTGACGCTTAAGGCACTGCAAGGAAAGCCACA
GAAGCTGCGTTTGTGGGTGGCGAAAGATTCAGTGTCCGAAGAAAATTGGCGTAACCTCAATCAATTATTACTGCAATATC
CCGACATTTGA

Antitoxin

Nucleotide

• Length: 87 bp

>AT140685 NZ_CP044316:1912712-1912798 [Enterococcus faecium]
CCGCTTAAGACGGTGGCGACATTAGTTATATCTAAAAAATAACCGCTGACTCGCTAAAGTAGACGGTTATTTTTTCTTGT
CATTTTT

Structures

Antitoxin