Detailed information of TA system TA140551

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1313292..1313663
• Replicon: chromosome
• Accession: NZ_CP044311
• Organism: Escherichia coli strain RM13752

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A839BBC2
• Locus tag: F7D06_RS06490
• Protein ID: WP_021500490.1
• Coordinates: 1313469..1313663 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1313292..1313470 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7D06_RS06465	1309247..1310620	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
F7D06_RS06470	1310749..1311684	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
F7D06_RS06475	1311736..1312971	-	1236	WP_072017917.1	site-specific integrase	-
F7D06_RS06480	1312973..1313188	-	216	WP_000079604.1	excisionase XisR	-
F7D06_RS06485	1313288..1313476	-	189	WP_151039308.1	DUF1187 family protein	-
-	1313292..1313470	+	179	NuclAT_0	-	Antitoxin
-	1313292..1313470	+	179	NuclAT_0	-	Antitoxin
-	1313292..1313470	+	179	NuclAT_0	-	Antitoxin
-	1313292..1313470	+	179	NuclAT_0	-	Antitoxin
F7D06_RS06490	1313469..1313663	-	195	WP_021500490.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
F7D06_RS06495	1313727..1314815	-	1089	WP_021529594.1	recombinase RecT	-
F7D06_RS06500	1314830..1317904	-	3075	WP_042973008.1	exodeoxyribonuclease VIII	-
F7D06_RS06505	1318006..1318280	-	275	Protein_1265	hypothetical protein	-
F7D06_RS06510	1318355..1318525	-	171	WP_001349883.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1311736..1358147	46411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7046.98 Da
• Isoelectric Point: 9.2886

>T140551 WP_021500490.1 NZ_CP044311:c1313663-1313469 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T140551 NZ_CP059298:256884-257168 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT140551 NZ_CP044311:1313292-1313470 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTTGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A839BBC2

Antitoxin