140533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1565124..1565817 Replicon chromosome
Accession NZ_CP044293
Organism Escherichia coli strain P276M

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag F6P95_RS07670 Protein ID WP_000415584.1
Coordinates 1565521..1565817 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag F6P95_RS07665 Protein ID WP_000650107.1
Coordinates 1565124..1565519 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6P95_RS07655 1560988..1563246 - 2259 WP_072777792.1 DNA topoisomerase IV subunit A -
F6P95_RS07660 1563384..1564991 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
F6P95_RS07665 1565124..1565519 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
F6P95_RS07670 1565521..1565817 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
F6P95_RS07675 1566022..1566504 - 483 WP_000183505.1 transcriptional regulator -
F6P95_RS07680 1566557..1566949 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
F6P95_RS07685 1567101..1567760 + 660 WP_001221493.1 two-component system response regulator QseB -
F6P95_RS07690 1567757..1569106 + 1350 WP_000673409.1 two-component system sensor histidine kinase QseC -
F6P95_RS07695 1569152..1569484 - 333 WP_000917684.1 DUF2645 family protein -
F6P95_RS07700 1569803..1570384 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
F6P95_RS07705 1570415..1570729 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T140533 WP_000415584.1 NZ_CP044293:c1565817-1565521 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T140533 NZ_CP059295:1678630-1678998 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCATGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTATGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT140533 WP_000650107.1 NZ_CP044293:c1565519-1565124 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT140533 NZ_CP059295:1678412-1678633 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References