Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1842054..1842618 Replicon chromosome
Accession NZ_CP044236
Organism Lacticaseibacillus paracasei strain WX322

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag F0M22_RS08895 Protein ID WP_016363448.1
Coordinates 1842054..1842356 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag F0M22_RS08900 Protein ID WP_003570051.1
Coordinates 1842349..1842618 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0M22_RS08875 1837367..1837924 + 558 WP_003584278.1 helix-turn-helix transcriptional regulator -
F0M22_RS08880 1838349..1840526 - 2178 WP_003570057.1 Tex family protein -
F0M22_RS08885 1840762..1841454 - 693 WP_003570055.1 hypothetical protein -
F0M22_RS08890 1841572..1841715 - 144 WP_162259784.1 hypothetical protein -
F0M22_RS08895 1842054..1842356 - 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
F0M22_RS08900 1842349..1842618 - 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F0M22_RS08905 1842992..1843645 - 654 WP_003570049.1 N-acetyltransferase -
F0M22_RS08910 1843690..1844319 - 630 WP_003570047.1 DUF2399 domain-containing protein -
F0M22_RS08915 1844382..1844708 - 327 WP_003584272.1 YrdB family protein -
F0M22_RS08920 1844701..1845105 - 405 WP_003570045.1 MerR family transcriptional regulator -
F0M22_RS08925 1845303..1846529 + 1227 WP_003570043.1 hypothetical protein -
F0M22_RS08930 1846726..1847613 + 888 WP_003570041.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T140480 WP_016363448.1 NZ_CP044236:c1842356-1842054 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T140480 NZ_CP044236:c1842356-1842054 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT140480 WP_003570051.1 NZ_CP044236:c1842618-1842349 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT140480 NZ_CP044236:c1842618-1842349 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References