Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 657141..657789 Replicon chromosome
Accession NZ_CP044230
Organism Streptococcus sp. LPB0220

Toxin (Protein)


Gene name higB Uniprot ID A0A428HW33
Locus tag LPB220_RS03500 Protein ID WP_049507635.1
Coordinates 657141..657506 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPB220_RS03505 Protein ID WP_021144391.1
Coordinates 657496..657789 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB220_RS03485 653194..655038 + 1845 WP_150905548.1 ATP-binding protein -
LPB220_RS03490 655042..655752 + 711 WP_150905549.1 hypothetical protein -
LPB220_RS03495 655749..656975 + 1227 WP_150905551.1 restriction endonuclease subunit S -
LPB220_RS03500 657141..657506 + 366 WP_049507635.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPB220_RS03505 657496..657789 + 294 WP_021144391.1 helix-turn-helix transcriptional regulator Antitoxin
LPB220_RS03510 657811..659412 + 1602 WP_150905553.1 type I restriction-modification system subunit M -
LPB220_RS03515 659528..660439 + 912 WP_150905555.1 Rpn family recombination-promoting nuclease/putative transposase -
LPB220_RS03520 660614..661759 - 1146 WP_150905557.1 site-specific integrase -
LPB220_RS03525 661867..662388 - 522 WP_150905558.1 hypothetical protein -
LPB220_RS03530 662405..662782 - 378 WP_150905560.1 ImmA/IrrE family metallo-endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 655749..701673 45924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14601.76 Da        Isoelectric Point: 10.0172

>T140477 WP_049507635.1 NZ_CP044230:657141-657506 [Streptococcus sp. LPB0220]
VHAIYFYKDKQGNQPVLDYMRELARRDNKDSRIKLNKLNDYIELLSQQGTRAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLRDEE

Download         Length: 366 bp

>T140477 NZ_CP059281:c2914667-2914560 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10730.48 Da        Isoelectric Point: 5.8962

>AT140477 WP_021144391.1 NZ_CP044230:657496-657789 [Streptococcus sp. LPB0220]
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKV

Download         Length: 294 bp

>AT140477 NZ_CP059281:2914715-2914781 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A428HW33

Antitoxin

Source ID Structure

References