140474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 942243..942786 Replicon chromosome
Accession NZ_CP044228
Organism Lacticaseibacillus rhamnosus strain hsryfm 1301

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag F5976_RS05060 Protein ID WP_005709630.1
Coordinates 942499..942786 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag F5976_RS05055 Protein ID WP_005714439.1
Coordinates 942243..942515 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5976_RS05035 937842..938942 - 1101 WP_005709638.1 metalloregulator ArsR/SmtB family transcription factor -
F5976_RS05040 939055..940428 + 1374 WP_005714442.1 MFS transporter -
F5976_RS05045 940591..941754 - 1164 WP_005709634.1 MFS transporter -
F5976_RS05050 941836..942129 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
F5976_RS05055 942243..942515 + 273 WP_005714439.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F5976_RS05060 942499..942786 + 288 WP_005709630.1 type II toxin-antitoxin system YafQ family toxin Toxin
F5976_RS05065 943010..944419 + 1410 WP_005714438.1 3'-5' exonuclease -
F5976_RS05070 944637..944816 + 180 WP_005709626.1 hypothetical protein -
F5976_RS05075 944927..945355 + 429 WP_005714437.1 OsmC family protein -
F5976_RS05080 945549..946568 + 1020 WP_005709622.1 dihydroxyacetone kinase subunit DhaK -
F5976_RS05085 946555..947136 + 582 WP_150861222.1 dihydroxyacetone kinase subunit L -
F5976_RS05090 947170..947538 + 369 WP_005686376.1 PTS-dependent dihydroxyacetone kinase phosphotransferase subunit DhaM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-67)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10888.77 Da        Isoelectric Point: 10.9032

>T140474 WP_005709630.1 NZ_CP044228:942499-942786 [Lacticaseibacillus rhamnosus]
MMLTINRTRTFKRQFKHLLRQGKDMTKLATAIDTLQRQDRVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALIL
MLLATGTHRDTLNIE

Download         Length: 288 bp

>T140474 NZ_CP059281:c2057491-2057273 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10073.49 Da        Isoelectric Point: 5.1154

>AT140474 WP_005714439.1 NZ_CP044228:942243-942515 [Lacticaseibacillus rhamnosus]
METKSRISVRIDTKTKERALHVLNSMGLDMSSAINMYLKRIGDTGELPFTPEMSFADQLQAAEADVKAGRTKSFKTVDAL
MKDLYNDVDD

Download         Length: 273 bp

>AT140474 NZ_CP059281:c2057891-2057517 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References