Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 2209007..2209602 Replicon chromosome
Accession NZ_CP044222
Organism Nitrincola sp. KXZD1103

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F5I99_RS10165 Protein ID WP_151055667.1
Coordinates 2209007..2209327 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F5I99_RS10170 Protein ID WP_151055669.1
Coordinates 2209324..2209602 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5I99_RS10140 2204144..2205646 - 1503 WP_151055657.1 aromatic/alkene/methane monooxygenase hydroxylase/oxygenase subunit alpha -
F5I99_RS10145 2205704..2205973 - 270 WP_151055659.1 MmoB/DmpM family protein -
F5I99_RS10150 2205984..2206970 - 987 WP_151055661.1 aromatic/alkene monooxygenase hydroxylase subunit beta -
F5I99_RS10155 2207004..2207309 - 306 WP_151055663.1 phenol hydroxylase -
F5I99_RS10160 2207702..2208781 + 1080 WP_151055665.1 PA0069 family radical SAM protein -
F5I99_RS10165 2209007..2209327 + 321 WP_151055667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F5I99_RS10170 2209324..2209602 + 279 WP_151055669.1 helix-turn-helix domain-containing protein Antitoxin
F5I99_RS10175 2209841..2210596 + 756 WP_151055671.1 DeoR/GlpR family DNA-binding transcription regulator -
F5I99_RS10180 2210607..2211683 + 1077 WP_151055673.1 ABC transporter ATP-binding protein -
F5I99_RS10185 2211667..2212947 + 1281 WP_151055675.1 ABC transporter substrate-binding protein -
F5I99_RS10190 2213023..2213895 + 873 WP_151055677.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12052.17 Da        Isoelectric Point: 9.7292

>T140467 WP_151055667.1 NZ_CP044222:2209007-2209327 [Nitrincola sp. KXZD1103]
MPWTIDFYDGVEEAITEMPPNIQARMLRLLELMEKHGANLGAPHSTPMGDGLFEIRAKAKEGIGRAIYCYMHGEHVYILH
AFIKKSQKTPKKDLNLAKTRMKKVSP

Download         Length: 321 bp

>T140467 NZ_CP059281:666323-666697 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10293.82 Da        Isoelectric Point: 7.8571

>AT140467 WP_151055669.1 NZ_CP044222:2209324-2209602 [Nitrincola sp. KXZD1103]
MSKLQQLKVRALQNPEVCQEYEALAEEFEFIDSLLKMRAAAGLTQEQLAERMGTKKSNISRLEKGGTNPSWGTLKKYAHA
CGFELSMSFHAA

Download         Length: 279 bp

>AT140467 NZ_CP059281:665865-666233 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References