Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 15748..16435 Replicon plasmid unnamed2
Accession NZ_CP044213
Organism Rhodococcus ruber strain C1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F1734_RS26030 Protein ID WP_140189311.1
Coordinates 15748..16119 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F1734_RS26035 Protein ID WP_140189310.1
Coordinates 16121..16435 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1734_RS26015 12394..12582 + 189 WP_140189314.1 hypothetical protein -
F1734_RS26020 12742..12924 - 183 WP_140189313.1 hypothetical protein -
F1734_RS26025 14040..15341 - 1302 WP_140189312.1 hypothetical protein -
F1734_RS26030 15748..16119 + 372 WP_140189311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1734_RS26035 16121..16435 + 315 WP_140189310.1 helix-turn-helix transcriptional regulator Antitoxin
F1734_RS26040 16761..17348 + 588 WP_140189309.1 ParA family protein -
F1734_RS26045 17345..17590 + 246 WP_140189308.1 hypothetical protein -
F1734_RS26050 17911..18201 - 291 WP_140189307.1 helix-turn-helix domain-containing protein -
F1734_RS26055 18201..19034 - 834 WP_140189319.1 replication initiation protein -
F1734_RS26060 19390..19647 + 258 WP_140189306.1 hypothetical protein -
F1734_RS26065 19614..19865 + 252 WP_140189305.1 hypothetical protein -
F1734_RS26070 19939..20145 - 207 WP_140189304.1 hypothetical protein -
F1734_RS26075 20518..20784 - 267 WP_203012080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45414 45414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13928.78 Da        Isoelectric Point: 4.7552

>T140457 WP_140189311.1 NZ_CP044213:15748-16119 [Rhodococcus ruber]
MAWEVVLLDEVDEWYLRLVRTDAETATAVTAAIDSLESEGPTLGRPLVDKVKGSHVHNMKELRPSGTSVRILFVFDPRRQ
AVLLVAGDKAGAWKQWYVDNIPRAEERYTMWLTEQNTSGTQEV

Download         Length: 372 bp

>T140457 NZ_CP059279:c4931418-4931311 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11964.42 Da        Isoelectric Point: 6.7327

>AT140457 WP_140189310.1 NZ_CP044213:16121-16435 [Rhodococcus ruber]
MARHWREVRADAAERLDEQAVTEARKSMQEEVRAYRLAEIRREQGWTRQEDVADLMGISQSRVSKIERGDLRHTELGTLE
SYVRALGGHLRVVAEFGDRSLTLG

Download         Length: 315 bp

>AT140457 NZ_CP059279:4931475-4931532 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References