Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2380107..2380740 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F6R98_RS10725 Protein ID WP_153249012.1
Coordinates 2380107..2380436 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F6R98_RS10730 Protein ID WP_153249013.1
Coordinates 2380426..2380740 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS10700 2376345..2376902 + 558 WP_153249007.1 SocA family protein -
F6R98_RS10705 2376899..2377342 + 444 WP_153249008.1 hypothetical protein -
F6R98_RS10710 2377395..2378459 - 1065 WP_153249009.1 phage antirepressor N-terminal domain-containing protein -
F6R98_RS10715 2378997..2379338 + 342 WP_153249010.1 DUF2845 domain-containing protein -
F6R98_RS10720 2379338..2379919 + 582 WP_153249011.1 hypothetical protein -
F6R98_RS10725 2380107..2380436 + 330 WP_153249012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6R98_RS10730 2380426..2380740 + 315 WP_153249013.1 helix-turn-helix domain-containing protein Antitoxin
F6R98_RS10735 2380873..2381196 + 324 Protein_2129 hypothetical protein -
F6R98_RS10740 2382345..2383388 - 1044 WP_153247527.1 IS30 family transposase -
F6R98_RS10745 2383444..2383911 + 468 WP_153249014.1 DUF1311 domain-containing protein -
F6R98_RS10750 2384006..2384455 - 450 WP_153249015.1 hypothetical protein -
F6R98_RS10755 2384645..2384932 + 288 WP_153249016.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2321320..2387876 66556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-99)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12417.43 Da        Isoelectric Point: 9.6571

>T140440 WP_153249012.1 NZ_CP044205:2380107-2380436 [Candidatus Methylospira mobilis]
MNYTITYYNEAVEADILALPATLRARYFSLSDRMEVYGANLGEPHTKAFGDGLFELRMKGAEGIARVFYCTLVGRRIVML
HSFVKKSQKTPPKELRIAVTRMNEVKNEP

Download         Length: 330 bp

>T140440 NZ_CP059279:985781-986068 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11499.20 Da        Isoelectric Point: 10.0394

>AT140440 WP_153249013.1 NZ_CP044205:2380426-2380740 [Candidatus Methylospira mobilis]
MNPERKPPTMTHAELKAKALADPEVRAEYERLNREEFAILDEILAARREAGLTQAQVAERMGTKAPAVARLESSLASGKH
SPSIDTLRKYAAALGKRLEVRFVS

Download         Length: 315 bp

>AT140440 NZ_CP059279:986055-986357 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References