Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1013613..1014115 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F6R98_RS04295 Protein ID WP_153247925.1
Coordinates 1013613..1013876 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F6R98_RS04300 Protein ID WP_153247926.1
Coordinates 1013873..1014115 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS04275 1009177..1010661 + 1485 WP_153247922.1 NADH-quinone oxidoreductase subunit M -
F6R98_RS04280 1010658..1012100 + 1443 WP_153247923.1 NADH-quinone oxidoreductase subunit N -
F6R98_RS04285 1012146..1012604 + 459 WP_153247924.1 hypothetical protein -
F6R98_RS04290 1012882..1013310 - 429 WP_194270132.1 Hsp20 family protein -
F6R98_RS04295 1013613..1013876 - 264 WP_153247925.1 Txe/YoeB family addiction module toxin Toxin
F6R98_RS04300 1013873..1014115 - 243 WP_153247926.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6R98_RS04305 1014281..1015045 - 765 WP_153247927.1 IS5 family transposase -
F6R98_RS04310 1015126..1015834 - 709 Protein_859 IS256 family transposase -
F6R98_RS04315 1016236..1017192 + 957 WP_153247928.1 thioredoxin-disulfide reductase -
F6R98_RS04320 1017251..1017931 - 681 WP_153247929.1 DUF2231 domain-containing protein -
F6R98_RS04330 1018356..1018706 + 351 WP_153247930.1 DUF2782 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10171.85 Da        Isoelectric Point: 10.2256

>T140436 WP_153247925.1 NZ_CP044205:c1013876-1013613 [Candidatus Methylospira mobilis]
VNWKLMYAKQALKDAKKLAASGLKPKAQELLAVLESNPFQNPPTFEKLVGDLQGAYSRRINIQHRLVYEVFETERIVRVL
RMWSHYE

Download         Length: 264 bp

>T140436 NZ_CP059279:120675-121049 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8860.10 Da        Isoelectric Point: 4.4547

>AT140436 WP_153247926.1 NZ_CP044205:c1014115-1013873 [Candidatus Methylospira mobilis]
MQTLTASEARANLYRLMDQAAESHQPIIITGKRTSAVLISNEDWQAIQETLFLLAVPGMRESIKQGMAEPLASSATELEW

Download         Length: 243 bp

>AT140436 NZ_CP059279:120217-120585 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References