Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 48455..49112 | Replicon | plasmid pAR-0401-1 |
| Accession | NZ_CP044189 | ||
| Organism | Salmonella enterica subsp. enterica serovar Albert strain AR-0401 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | F4V13_RS24685 | Protein ID | WP_000270043.1 |
| Coordinates | 48455..48805 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | F4V13_RS24690 | Protein ID | WP_000124640.1 |
| Coordinates | 48810..49112 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F4V13_RS24630 | 43820..43999 | + | 180 | Protein_54 | helix-turn-helix transcriptional regulator | - |
| F4V13_RS24635 | 44064..44768 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| F4V13_RS24645 | 44929..45426 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| F4V13_RS24650 | 45429..45917 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| F4V13_RS24655 | 46014..46349 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| F4V13_RS24660 | 46364..46834 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| F4V13_RS24665 | 46827..47198 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| F4V13_RS24670 | 47209..47403 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| F4V13_RS24680 | 47744..48292 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| F4V13_RS24685 | 48455..48805 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| F4V13_RS24690 | 48810..49112 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| F4V13_RS24695 | 49139..49432 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| F4V13_RS24700 | 49520..49792 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| F4V13_RS24705 | 49850..50377 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| F4V13_RS24715 | 50608..51465 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| F4V13_RS24720 | 51452..51682 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| F4V13_RS24725 | 51682..52200 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| F4V13_RS24730 | 52197..52643 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| F4V13_RS24735 | 52643..53002 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| F4V13_RS24740 | 53059..53487 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..90935 | 90935 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T140430 WP_000270043.1 NZ_CP044189:48455-48805 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T140430 NZ_CP059180:c1853345-1853193 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT140430 WP_000124640.1 NZ_CP044189:48810-49112 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT140430 NZ_CP059180:c1853969-1853370 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|