Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1558896..1559116 Replicon chromosome
Accession NZ_CP044158
Organism Shigella flexneri strain AR-0423

Toxin (Protein)


Gene name ldrD Uniprot ID A0A4P7TT65
Locus tag F4V35_RS07985 Protein ID WP_000170961.1
Coordinates 1558896..1559003 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1559050..1559116 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V35_RS07960 1554740..1555822 + 1083 WP_000804726.1 peptide chain release factor 1 -
F4V35_RS07965 1555822..1556655 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
F4V35_RS07970 1556652..1557044 + 393 WP_000200378.1 invasion regulator SirB2 -
F4V35_RS07975 1557048..1557857 + 810 WP_001257042.1 invasion regulator SirB1 -
F4V35_RS07980 1557893..1558747 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
F4V35_RS07985 1558896..1559003 - 108 WP_000170961.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 1559050..1559116 + 67 - - Antitoxin
F4V35_RS07995 1559408..1560508 - 1101 WP_000063614.1 sodium-potassium/proton antiporter ChaA -
F4V35_RS08000 1560778..1561008 + 231 WP_001146444.1 putative cation transport regulator ChaB -
F4V35_RS08005 1561166..1561861 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
F4V35_RS08010 1561905..1562258 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
F4V35_RS08015 1562443..1563837 + 1395 WP_000086222.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3971.74 Da        Isoelectric Point: 11.4779

>T140401 WP_000170961.1 NZ_CP044158:c1559003-1558896 [Shigella flexneri]
MTLAQFAMTFWHDLAAPILAGIIAAAIVSWWRNRK

Download         Length: 108 bp

>T140401 NZ_CP059155:c2092960-2092784 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 67 bp

>AT140401 NZ_CP044158:1559050-1559116 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TT65

Antitoxin

Download structure file

References