Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ldrD-rdlD/Ldr(toxin) |
| Location | 2798265..2798487 | Replicon | chromosome |
| Accession | NZ_CP044152 | ||
| Organism | Shigella flexneri strain AR-0425 | ||
Toxin (Protein)
| Gene name | ldrD | Uniprot ID | S1NWX0 |
| Locus tag | F4V37_RS14220 | Protein ID | WP_001295224.1 |
| Coordinates | 2798380..2798487 (+) | Length | 36 a.a. |
Antitoxin (RNA)
| Gene name | rdlD | ||
| Locus tag | - | ||
| Coordinates | 2798265..2798331 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F4V37_RS14195 | 2793706..2794608 | + | 903 | WP_000084666.1 | dipeptide ABC transporter permease DppC | - |
| F4V37_RS14200 | 2794619..2795602 | + | 984 | WP_001196486.1 | dipeptide ABC transporter ATP-binding protein | - |
| F4V37_RS14205 | 2795599..2796603 | + | 1005 | WP_000107041.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| F4V37_RS14210 | 2796633..2797904 | - | 1272 | WP_005052340.1 | aromatic amino acid transport family protein | - |
| - | 2798265..2798331 | - | 67 | - | - | Antitoxin |
| F4V37_RS14220 | 2798380..2798487 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | Toxin |
| - | 2798749..2798805 | - | 57 | NuclAT_23 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_23 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_23 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_23 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_26 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_26 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_26 | - | - |
| - | 2798749..2798805 | - | 57 | NuclAT_26 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_29 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_29 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_29 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_29 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_32 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_32 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_32 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_32 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_35 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_35 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_35 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_35 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_38 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_38 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_38 | - | - |
| - | 2798751..2798805 | - | 55 | NuclAT_38 | - | - |
| F4V37_RS14230 | 2798863..2798970 | + | 108 | WP_000141634.1 | type I toxin-antitoxin system toxic polypeptide LdrD | - |
| - | 2799232..2799289 | - | 58 | NuclAT_24 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_24 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_24 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_24 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_27 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_27 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_27 | - | - |
| - | 2799232..2799289 | - | 58 | NuclAT_27 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_30 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_30 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_30 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_30 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_33 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_33 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_33 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_33 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_36 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_36 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_36 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_36 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_39 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_39 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_39 | - | - |
| - | 2799234..2799289 | - | 56 | NuclAT_39 | - | - |
| F4V37_RS14240 | 2799346..2799453 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 2799715..2799772 | - | 58 | NuclAT_22 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_22 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_22 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_22 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_25 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_25 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_25 | - | - |
| - | 2799715..2799772 | - | 58 | NuclAT_25 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_28 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_28 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_28 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_28 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_31 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_31 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_31 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_31 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_34 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_34 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_34 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_34 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_37 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_37 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_37 | - | - |
| - | 2799717..2799772 | - | 56 | NuclAT_37 | - | - |
| F4V37_RS14250 | 2799829..2799936 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| F4V37_RS14255 | 2800023..2801702 | - | 1680 | WP_000191557.1 | cellulose biosynthesis protein BcsG | - |
| F4V37_RS14260 | 2801699..2801890 | - | 192 | WP_000988299.1 | cellulose biosynthesis protein BcsF | - |
| F4V37_RS14265 | 2801887..2803458 | - | 1572 | WP_001204920.1 | cellulose biosynthesis c-di-GMP-binding protein BcsE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 3882.70 Da Isoelectric Point: 9.0157
>T140352 WP_001295224.1 NZ_CP044152:2798380-2798487 [Shigella flexneri]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK
Download Length: 108 bp
>T140352 NZ_CP059125:c2203666-2202344 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA
Antitoxin
Download Length: 67 bp
>AT140352 NZ_CP044152:c2798331-2798265 [Shigella flexneri]
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
