140350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1492115..1492959 Replicon chromosome
Accession NZ_CP044152
Organism Shigella flexneri strain AR-0425

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag F4V37_RS07930 Protein ID WP_014532172.1
Coordinates 1492498..1492959 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag F4V37_RS07920 Protein ID WP_005053053.1
Coordinates 1492115..1492426 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V37_RS07895 (1487586) 1487586..1488083 + 498 Protein_1523 COX aromatic rich motif-containing protein -
F4V37_RS07900 (1488105) 1488105..1490096 + 1992 Protein_1524 cytochrome o ubiquinol oxidase subunit I -
F4V37_RS07905 (1490086) 1490086..1490700 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
F4V37_RS07910 (1490700) 1490700..1491029 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
F4V37_RS07915 (1491041) 1491041..1491931 + 891 WP_000971346.1 heme o synthase -
F4V37_RS07920 (1492115) 1492115..1492426 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
F4V37_RS07930 (1492498) 1492498..1492959 + 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
F4V37_RS07940 (1493855) 1493855..1496008 + 2154 WP_005060811.1 SEL1-like repeat protein -
F4V37_RS07945 (1496061) 1496061..1497791 + 1731 WP_000645013.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1493007..1493510 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T140350 WP_014532172.1 NZ_CP044152:1492498-1492959 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

>T140350 NZ_CP059125:c1912131-1912024 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT140350 WP_005053053.1 NZ_CP044152:1492115-1492426 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT140350 NZ_CP059125:1912184-1912245 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References