Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3986343..3986884 Replicon chromosome
Accession NZ_CP044151
Organism Shigella sonnei strain AR-0426

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag F4V38_RS20460 Protein ID WP_000615976.1
Coordinates 3986343..3986621 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag F4V38_RS20465 Protein ID WP_000729704.1
Coordinates 3986624..3986884 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V38_RS20445 (3983925) 3983925..3984503 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
F4V38_RS20450 (3984709) 3984709..3985476 + 768 WP_000333380.1 class II glutamine amidotransferase -
F4V38_RS20455 (3985447) 3985447..3986187 - 741 WP_119170906.1 peptidoglycan meso-diaminopimelic acid protein amidase -
F4V38_RS20460 (3986343) 3986343..3986621 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
F4V38_RS20465 (3986624) 3986624..3986884 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
F4V38_RS25945 (3987012) 3987012..3987176 - 165 WP_237158187.1 hypothetical protein -
F4V38_RS20470 (3987100) 3987100..3987843 + 744 WP_237158188.1 C40 family peptidase -
F4V38_RS20480 (3988884) 3988884..3989012 + 129 Protein_3953 ISAs1 family transposase -
F4V38_RS20485 (3989083) 3989083..3989580 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
F4V38_RS20490 (3989703) 3989703..3991415 - 1713 Protein_3955 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3976194..3989580 13386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T140335 WP_000615976.1 NZ_CP044151:c3986621-3986343 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T140335 NZ_CP059119:2744477-2744584 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT140335 WP_000729704.1 NZ_CP044151:c3986884-3986624 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT140335 NZ_CP059119:c2744430-2744364 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References