Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 3986343..3986884 | Replicon | chromosome |
| Accession | NZ_CP044151 | ||
| Organism | Shigella sonnei strain AR-0426 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | U9XPG0 |
| Locus tag | F4V38_RS20460 | Protein ID | WP_000615976.1 |
| Coordinates | 3986343..3986621 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | S1EWQ0 |
| Locus tag | F4V38_RS20465 | Protein ID | WP_000729704.1 |
| Coordinates | 3986624..3986884 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F4V38_RS20445 (3983925) | 3983925..3984503 | + | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase | - |
| F4V38_RS20450 (3984709) | 3984709..3985476 | + | 768 | WP_000333380.1 | class II glutamine amidotransferase | - |
| F4V38_RS20455 (3985447) | 3985447..3986187 | - | 741 | WP_119170906.1 | peptidoglycan meso-diaminopimelic acid protein amidase | - |
| F4V38_RS20460 (3986343) | 3986343..3986621 | - | 279 | WP_000615976.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | Toxin |
| F4V38_RS20465 (3986624) | 3986624..3986884 | - | 261 | WP_000729704.1 | type II toxin-antitoxin system antitoxin DinJ | Antitoxin |
| F4V38_RS25945 (3987012) | 3987012..3987176 | - | 165 | WP_237158187.1 | hypothetical protein | - |
| F4V38_RS20470 (3987100) | 3987100..3987843 | + | 744 | WP_237158188.1 | C40 family peptidase | - |
| F4V38_RS20480 (3988884) | 3988884..3989012 | + | 129 | Protein_3953 | ISAs1 family transposase | - |
| F4V38_RS20485 (3989083) | 3989083..3989580 | + | 498 | WP_000006258.1 | REP-associated tyrosine transposase RayT | - |
| F4V38_RS20490 (3989703) | 3989703..3991415 | - | 1713 | Protein_3955 | flagellar biosynthesis protein FlhA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | gmhA/lpcA | 3976194..3989580 | 13386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10800.59 Da Isoelectric Point: 10.0702
>T140335 WP_000615976.1 NZ_CP044151:c3986621-3986343 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
Download Length: 279 bp
>T140335 NZ_CP059119:2744477-2744584 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9391.77 Da Isoelectric Point: 5.0758
>AT140335 WP_000729704.1 NZ_CP044151:c3986884-3986624 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
Download Length: 261 bp
>AT140335 NZ_CP059119:c2744430-2744364 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XPG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y6Z6 |