Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5145072..5145867 Replicon chromosome
Accession NZ_CP044148
Organism Escherichia coli O157 strain AR-0427

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag F4V39_RS25890 Protein ID WP_000854914.1
Coordinates 5145493..5145867 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag F4V39_RS25885 Protein ID WP_001280954.1
Coordinates 5145072..5145446 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V39_RS25850 5140427..5141332 + 906 WP_000203541.1 chemotaxis protein -
F4V39_RS25855 5141329..5142399 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
F4V39_RS25865 5142739..5143557 + 819 WP_001234682.1 DUF945 domain-containing protein -
F4V39_RS25870 5143648..5144133 + 486 WP_000214398.1 antirestriction protein -
F4V39_RS25875 5144149..5144625 + 477 WP_001186738.1 RadC family protein -
F4V39_RS25880 5144688..5144909 + 222 WP_001220314.1 DUF987 domain-containing protein -
F4V39_RS25885 5145072..5145446 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F4V39_RS25890 5145493..5145867 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
F4V39_RS25895 5145864..5146355 + 492 WP_000976853.1 hypothetical protein -
F4V39_RS25900 5146367..5146564 + 198 WP_000839282.1 DUF957 domain-containing protein -
F4V39_RS25905 5146649..5147491 + 843 WP_001280481.1 DUF4942 domain-containing protein -
F4V39_RS25915 5147962..5148900 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
F4V39_RS25920 5148955..5149692 + 738 WP_000283664.1 zinc-binding phosphatase -
F4V39_RS25925 5149716..5150270 + 555 WP_001001917.1 molecular chaperone YcdY -
F4V39_RS25930 5150372..5150863 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 5144149..5156431 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T140310 WP_000854914.1 NZ_CP044148:5145493-5145867 [Escherichia coli O157]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T140310 NZ_CP059088:66826-67113 [Pantoea agglomerans]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAGCTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGTTTTCGTTTGGTTTATCAGGTAATAGACGATCAGCTGGTAATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAGAGGATGCGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT140310 WP_001280954.1 NZ_CP044148:5145072-5145446 [Escherichia coli O157]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT140310 NZ_CP059088:66578-66829 [Pantoea agglomerans]
ATGCCAAACATTATTTTAAGCGATACCAGTGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAATGCAGG
TGACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTGTATGAACAGATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAGCGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References