Detailed information of TA system TA140294

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2697853..2698074
• Replicon: chromosome
• Accession: NZ_CP044148
• Organism: Escherichia coli O157 strain AR-0427

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: F4V39_RS14075
• Protein ID: WP_001295224.1
• Coordinates: 2697853..2697960 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2698009..2698074 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4V39_RS14050	2693106..2693858	-	753	Protein_2682	cellulose biosynthesis protein BcsQ	-
F4V39_RS14055	2693870..2694058	-	189	WP_001063316.1	YhjR family protein	-
F4V39_RS14060	2694331..2695902	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
F4V39_RS14065	2695899..2696090	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
F4V39_RS14070	2696087..2697766	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
F4V39_RS14075	2697853..2697960	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2698009..2698074	+	66	NuclAT_16	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_16	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_16	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_16	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_21	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_21	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_21	-	Antitoxin
-	2698009..2698074	+	66	NuclAT_21	-	Antitoxin
F4V39_RS14085	2698436..2699707	+	1272	WP_001301684.1	amino acid permease	-
F4V39_RS14090	2699737..2700741	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
F4V39_RS14095	2700738..2701721	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
F4V39_RS14100	2701732..2702634	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T140294 WP_001295224.1 NZ_CP044148:c2697960-2697853 [Escherichia coli O157]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T140294 NZ_CP059082:4912093-4912344 [Halomonas titanicae]
ATGGATGCTATCAGCTACACAGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCACCTAT
GATCATCACCCGAAGCAAGGCGCAATCCGTGGTAATGATCTCTCTCGAAGACTATGAGGCGCTGCAAGAGACAGCCTATC
TTCTGCGCGCACCTAAGAACGCCCGCCGTTTGCTGGAATCCGTTGCCGAATTGGAACAAGGTGGTGGTCAGGAGAAGGAA
CTTCTTGAATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT140294 NZ_CP044148:2698009-2698074 [Escherichia coli O157]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin