Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 2230502..2231229 | Replicon | chromosome |
Accession | NZ_CP044148 | ||
Organism | Escherichia coli O157 strain AR-0427 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | F4V39_RS11720 | Protein ID | WP_000550189.1 |
Coordinates | 2230915..2231229 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | F4V39_RS11715 | Protein ID | WP_000560249.1 |
Coordinates | 2230502..2230918 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F4V39_RS11705 | 2225562..2227913 | + | 2352 | WP_000695517.1 | alpha-glucosidase | - |
F4V39_RS11710 | 2228439..2230457 | + | 2019 | WP_000121479.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
F4V39_RS11715 | 2230502..2230918 | - | 417 | WP_000560249.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
F4V39_RS11720 | 2230915..2231229 | - | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
F4V39_RS11725 | 2231513..2232649 | - | 1137 | WP_000018678.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
F4V39_RS11730 | 2232734..2233237 | + | 504 | WP_001295542.1 | M48 family metallopeptidase | - |
F4V39_RS11735 | 2233314..2234006 | + | 693 | WP_000942544.1 | vancomycin high temperature exclusion protein | - |
F4V39_RS11740 | 2234085..2235071 | + | 987 | WP_000617675.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T140288 WP_000550189.1 NZ_CP044148:c2231229-2230915 [Escherichia coli O157]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T140288 NZ_CP059082:c1816495-1816232 [Halomonas titanicae]
ATGAGTAACCGCTTACTATGTTGGACTAACGAAGCTTGGAGCGACTACCTCTATTGGCAGGGGCAGGATAAAAAGACCTT
AAAGCGCATCAATAAACTTATCTTAGATACGCAGCGTTCTCCCTTTGAGGGCATTGGAAAACCTGAGCCCCTAAGGGAAA
ACCTCTCTGGCTTCTGGTCACGACGCATCGACGACTCGCATCGTCTGATTTATGCCGTCGATGAATCCACTCTCACTATC
ATTGCCTGTCGCTACCATTACTAA
ATGAGTAACCGCTTACTATGTTGGACTAACGAAGCTTGGAGCGACTACCTCTATTGGCAGGGGCAGGATAAAAAGACCTT
AAAGCGCATCAATAAACTTATCTTAGATACGCAGCGTTCTCCCTTTGAGGGCATTGGAAAACCTGAGCCCCTAAGGGAAA
ACCTCTCTGGCTTCTGGTCACGACGCATCGACGACTCGCATCGTCTGATTTATGCCGTCGATGAATCCACTCTCACTATC
ATTGCCTGTCGCTACCATTACTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15016.48 Da Isoelectric Point: 4.5805
>AT140288 WP_000560249.1 NZ_CP044148:c2230918-2230502 [Escherichia coli O157]
MIAIADILHAGEKLTAVAPFLAGIQNEEQYIQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILHAGEKLTAVAPFLAGIQNEEQYIQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT140288 NZ_CP059082:c1816742-1816488 [Halomonas titanicae]
ATGCGTGTTATATCGTTTACCGAAGCGCGTAATGGTCTAAAAGGCGTACTGGACGGTGTGGTCAATGATGCCGATACCAC
GATTATCACCCGCCGCGACGCAGAAGATGCAGTGGTCATGTCACTTGACTACTATAACAGCCTTATGGAAACCGTTTACT
TGATGCGCTCACCTGCTAACGCAGAGCACTTAAACAAGTCCATTGCTCAATACCGTGCAGGGCAAGCTCAACCAAGAGAG
CTAATGGATGAGTAA
ATGCGTGTTATATCGTTTACCGAAGCGCGTAATGGTCTAAAAGGCGTACTGGACGGTGTGGTCAATGATGCCGATACCAC
GATTATCACCCGCCGCGACGCAGAAGATGCAGTGGTCATGTCACTTGACTACTATAACAGCCTTATGGAAACCGTTTACT
TGATGCGCTCACCTGCTAACGCAGAGCACTTAAACAAGTCCATTGCTCAATACCGTGCAGGGCAAGCTCAACCAAGAGAG
CTAATGGATGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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