Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 1861031..1861443 Replicon chromosome
Accession NZ_CP044143
Organism Escherichia coli O157 strain AR-0429

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag F4V41_RS10500 Protein ID WP_000132630.1
Coordinates 1861102..1861443 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1861031..1861107 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V41_RS10490 1857658..1859127 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
F4V41_RS10495 1859127..1860881 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 1861031..1861107 - 77 NuclAT_15 - Antitoxin
- 1861031..1861107 - 77 NuclAT_15 - Antitoxin
- 1861031..1861107 - 77 NuclAT_15 - Antitoxin
- 1861031..1861107 - 77 NuclAT_15 - Antitoxin
- 1861031..1861107 - 77 NuclAT_16 - Antitoxin
- 1861031..1861107 - 77 NuclAT_16 - Antitoxin
- 1861031..1861107 - 77 NuclAT_16 - Antitoxin
- 1861031..1861107 - 77 NuclAT_16 - Antitoxin
F4V41_RS10500 1861102..1861443 + 342 WP_000132630.1 endoribonuclease SymE Toxin
F4V41_RS10505 1861490..1862653 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
F4V41_RS10510 1862701..1863582 - 882 WP_001304007.1 DUF262 domain-containing protein -
F4V41_RS10515 1863679..1863843 - 165 WP_000394274.1 DUF1127 domain-containing protein -
F4V41_RS10520 1864020..1865432 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
F4V41_RS29415 1865675..1865875 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 1853230..1874463 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T140214 WP_000132630.1 NZ_CP044143:1861102-1861443 [Escherichia coli O157]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T140214 NZ_CP059043:c1703242-1703135 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT140214 NZ_CP044143:c1861107-1861031 [Escherichia coli O157]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References