Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 1274036..1274448 Replicon chromosome
Accession NZ_CP044140
Organism Escherichia coli O157 strain AR-0430

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag F4V42_RS07530 Protein ID WP_000132630.1
Coordinates 1274107..1274448 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1274036..1274112 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V42_RS07520 1270663..1272132 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
F4V42_RS07525 1272132..1273886 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 1274036..1274112 - 77 NuclAT_15 - Antitoxin
- 1274036..1274112 - 77 NuclAT_15 - Antitoxin
- 1274036..1274112 - 77 NuclAT_15 - Antitoxin
- 1274036..1274112 - 77 NuclAT_15 - Antitoxin
- 1274036..1274112 - 77 NuclAT_16 - Antitoxin
- 1274036..1274112 - 77 NuclAT_16 - Antitoxin
- 1274036..1274112 - 77 NuclAT_16 - Antitoxin
- 1274036..1274112 - 77 NuclAT_16 - Antitoxin
F4V42_RS07530 1274107..1274448 + 342 WP_000132630.1 endoribonuclease SymE Toxin
F4V42_RS07535 1274495..1275658 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
F4V42_RS07540 1275706..1276587 - 882 WP_001304007.1 DUF262 domain-containing protein -
F4V42_RS07545 1276684..1276848 - 165 WP_000394274.1 DUF1127 domain-containing protein -
F4V42_RS07550 1277025..1278437 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
F4V42_RS29965 1278680..1278880 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 1266235..1287473 21238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T140178 WP_000132630.1 NZ_CP044140:1274107-1274448 [Escherichia coli O157]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T140178 NZ_CP059003:1951694-1951796 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 bp

>AT140178 NZ_CP044140:c1274112-1274036 [Escherichia coli O157]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References