140107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2172658..2173333 Replicon chromosome
Accession NZ_CP044107
Organism Enterobacter hormaechei strain FDAARGOS_642

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag FOB50_RS10455 Protein ID WP_015571638.1
Coordinates 2173034..2173333 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag FOB50_RS10450 Protein ID WP_015571639.1
Coordinates 2172658..2173023 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB50_RS10430 2169114..2169845 + 732 WP_039269965.1 class I SAM-dependent methyltransferase -
FOB50_RS10435 2169842..2170444 - 603 WP_017382759.1 short chain dehydrogenase -
FOB50_RS10440 2170542..2171429 + 888 WP_015571641.1 LysR family transcriptional regulator -
FOB50_RS10445 2171450..2172631 + 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
FOB50_RS10450 2172658..2173023 - 366 WP_015571639.1 HigA family addiction module antidote protein Antitoxin
FOB50_RS10455 2173034..2173333 - 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB50_RS10460 2173584..2174744 - 1161 WP_085929677.1 HlyD family efflux transporter periplasmic adaptor subunit -
FOB50_RS10465 2174764..2176956 - 2193 WP_017692801.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T140107 WP_015571638.1 NZ_CP044107:c2173333-2173034 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T140107 NZ_CP058948:c1702707-1702600 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT140107 WP_015571639.1 NZ_CP044107:c2173023-2172658 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT140107 NZ_CP058948:1702754-1702820 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References