Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2636293..2636810 Replicon chromosome
Accession NZ_CP044106
Organism Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag FOB68_RS13290 Protein ID WP_000113263.1
Coordinates 2636544..2636810 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FOB68_RS13285 Protein ID WP_000584499.1
Coordinates 2636293..2636544 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB68_RS13255 2631993..2632712 + 720 WP_000479576.1 amino acid ABC transporter permease -
FOB68_RS13260 2632709..2633440 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
FOB68_RS13265 2633537..2634787 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
FOB68_RS13270 2635042..2635404 + 363 WP_000819839.1 DUF4467 domain-containing protein -
FOB68_RS13275 2635423..2636022 + 600 WP_000162810.1 DsbA family protein -
FOB68_RS13280 2636029..2636120 + 92 Protein_2488 hypothetical protein -
FOB68_RS13285 2636293..2636544 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOB68_RS13290 2636544..2636810 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
FOB68_RS13295 2637104..2638651 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FOB68_RS13300 2638837..2639304 + 468 WP_000153338.1 SRPBCC domain-containing protein -
FOB68_RS13305 2639391..2639573 + 183 WP_000079140.1 hypothetical protein -
FOB68_RS13310 2639777..2640601 + 825 WP_000594633.1 formate/nitrite transporter family protein -
FOB68_RS13315 2641014..2641550 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T140103 WP_000113263.1 NZ_CP044106:2636544-2636810 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T140103 NZ_CP058948:c643965-643687 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT140103 WP_000584499.1 NZ_CP044106:2636293-2636544 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT140103 NZ_CP058948:c644228-643968 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References