Detailed information of TA system TA140096

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 798488..798826
• Replicon: chromosome
• Accession: NZ_CP044106
• Organism: Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FOB68_RS04360
• Protein ID: WP_011447039.1
• Coordinates: 798488..798664 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	798652..798826 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB68_RS04340	793723..797508	+	3786	WP_000582158.1	hypothetical protein	-
FOB68_RS04345	797498..797650	+	153	WP_001153681.1	hypothetical protein	-
FOB68_RS04350	797697..797984	+	288	WP_001040261.1	hypothetical protein	-
FOB68_RS04355	798042..798338	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
FOB68_RS04360	798488..798664	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	798652..798826	-	175	-	-	Antitoxin
FOB68_RS04370	798876..799130	+	255	WP_000611512.1	phage holin	-
FOB68_RS04375	799142..799897	+	756	WP_000861038.1	CHAP domain-containing protein	-
FOB68_RS04380	800088..800579	+	492	WP_000919350.1	staphylokinase	-
FOB68_RS04390	801229..801564	+	336	Protein_777	SH3 domain-containing protein	-
FOB68_RS04395	801659..802108	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
FOB68_RS04400	802788..803138	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
FOB68_RS04405	803191..803451	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	748130..803138	55008

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T140096 WP_011447039.1 NZ_CP044106:798488-798664 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T140096 NZ_CP058940:3726317-3726419 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 175 bp

>AT140096 NZ_CP044106:c798826-798652 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin