Detailed information of TA system TA140088

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 95621..95884
• Replicon: chromosome
• Accession: NZ_CP044106
• Organism: Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FOB68_RS00645
• Protein ID: WP_001802298.1
• Coordinates: 95621..95725 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	95720..95884 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB68_RS00620	91015..91797	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
FOB68_RS00625	91865..92722	+	858	WP_031844942.1	Cof-type HAD-IIB family hydrolase	-
FOB68_RS00630	93417..93509	-	93	WP_031844941.1	hypothetical protein	-
FOB68_RS00635	93798..94934	+	1137	Protein_89	SAP domain-containing protein	-
FOB68_RS00640	94977..95460	+	484	Protein_90	recombinase family protein	-
FOB68_RS00645	95621..95725	+	105	WP_001802298.1	hypothetical protein	Toxin
-	95720..95884	-	165	-	-	Antitoxin
FOB68_RS00650	96174..97265	-	1092	WP_000495695.1	hypothetical protein	-
FOB68_RS00655	97531..98508	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
FOB68_RS00660	98510..98830	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FOB68_RS00665	98982..99647	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T140088 WP_001802298.1 NZ_CP044106:95621-95725 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T140088 NZ_CP058940:624505-624723 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT140088 NZ_CP044106:c95884-95720 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin