Detailed information of TA system TA140087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4314..4728
• Replicon: chromosome
• Accession: NZ_CP044106
• Organism: Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FOB68_RS00195
• Protein ID: WP_061823638.1
• Coordinates: 4314..4565 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FOB68_RS14490
• Protein ID: WP_000028424.1
• Coordinates: 4555..4728 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB68_RS00150	1682..1867	+	186	WP_001164629.1	DUF3113 family protein	-
FOB68_RS00155	1867..2268	+	402	WP_000113974.1	PVL family protein	-
FOB68_RS00160	2268..2525	+	258	WP_000022728.1	DUF3310 domain-containing protein	-
FOB68_RS00165	2528..2728	+	201	WP_031837453.1	hypothetical protein	-
FOB68_RS00170	2743..2985	+	243	WP_150344353.1	hypothetical protein	-
FOB68_RS00175	3026..3403	+	378	WP_150344354.1	hypothetical protein	-
FOB68_RS00180	3400..3594	+	195	WP_000983954.1	hypothetical protein	-
FOB68_RS00185	3591..4040	+	450	WP_000982708.1	hypothetical protein	-
FOB68_RS00190	4037..4321	+	285	WP_150344355.1	hypothetical protein	-
FOB68_RS00195	4314..4565	+	252	WP_061823638.1	DUF1024 family protein	Toxin
FOB68_RS14490	4555..4728	+	174	WP_000028424.1	hypothetical protein	Antitoxin
FOB68_RS14495	4729..4890	+	162	WP_190812352.1	hypothetical protein	-
FOB68_RS00200	4905..5432	+	528	WP_072473165.1	dUTPase	-
FOB68_RS00205	5469..5714	+	246	WP_150344356.1	hypothetical protein	-
FOB68_RS00210	5711..5917	+	207	WP_000195791.1	DUF1381 domain-containing protein	-
FOB68_RS00215	5914..6066	+	153	WP_000595263.1	transcriptional activator RinB	-
FOB68_RS00220	6134..6334	+	201	WP_000265258.1	DUF1514 family protein	-
FOB68_RS00225	6386..8833	+	2448	WP_150344357.1	virulence-associated E family protein	-
FOB68_RS00230	8936..9031	-	96	WP_031764095.1	hypothetical protein	-
FOB68_RS00235	9174..9464	+	291	WP_001794602.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	17..36874	36857

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9403.30 Da
• Isoelectric Point: 3.8567

>T140087 WP_061823638.1 NZ_CP044106:4314-4565 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAIGIMAGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T140087 NZ_CP058908:2150130-2150444 [Pseudomonas phenolilytica]
ATGATCTTTATCGAGACGCCGATGTTTACCAAGCGCCTGCGGGAGCTGCTCAGCGATGACAGCTATGCGGAGTTTCAACG
GCAATTGGCTGATCGGCCCGACATGGGAGACGTGATCGAAGGTACTGGCGGCATCCGCAAGGTTCGAGTTGCGTCCAGTG
GTCACGGCAAGCGAGGCGGCTCCAGGGTCATCTACTACCACTTCACGGCTGCTTCGCAGATCGCGCTTCTGCTGATCTAC
CCGAAGAACGAGAAGGACGACCTTACGGCAGACGAGCGCAAGGTGCTCAAGCAAATCATCGAGCGGTGGAGGTAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT140087 WP_000028424.1 NZ_CP044106:4555-4728 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT140087 NZ_CP058908:2150450-2150740 [Pseudomonas phenolilytica]
ATGAGTAGATTCTTCGAAGACCTTCTGGAAAGCGTCCAGCAGATGGATGAGATCCGGCGAGGCGAGCGACAGCCTTCGCG
GGAGTTCACCGTGGATGCTCTGCAGGTGAAGGAAATCCGCAAGGCAACCGGGCTGACTCAGGCCAAGTTTGCGGCGATGA
TCGATGTTCAGCTCGGCACGCTGCGCAATTGGGAACAAGGCCGACGCGAACCGACCGGTCCGGCCAAGGCGCTGCTGCGC
GCTATTCATAACGATCCGAAGCACGTTATCCAGGCGCTTTCGTCCGTCTGA