Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1980744..1981408 Replicon chromosome
Accession NZ_CP044098
Organism Citrobacter portucalensis strain FDAARGOS_617

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOB25_RS09390 Protein ID WP_032942116.1
Coordinates 1981106..1981408 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5A9BY49
Locus tag FOB25_RS09385 Protein ID WP_008786950.1
Coordinates 1980744..1981085 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB25_RS09355 1975855..1976613 + 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -
FOB25_RS09360 1977127..1977813 + 687 WP_003826708.1 phosphonate C-P lyase system protein PhnL -
FOB25_RS09365 1977810..1978946 + 1137 WP_032942122.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
FOB25_RS09370 1978949..1979503 + 555 WP_008786953.1 ribose 1,5-bisphosphokinase -
FOB25_RS09375 1979490..1979924 + 435 WP_008786952.1 aminoalkylphosphonate N-acetyltransferase -
FOB25_RS09380 1979933..1980691 + 759 WP_032942120.1 phosphonate metabolism protein PhnP -
FOB25_RS09385 1980744..1981085 - 342 WP_008786950.1 HigA family addiction module antidote protein Antitoxin
FOB25_RS09390 1981106..1981408 - 303 WP_032942116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB25_RS09395 1981564..1981893 - 330 WP_003031807.1 hypothetical protein -
FOB25_RS09400 1981963..1984227 - 2265 WP_032942115.1 hybrid sensor histidine kinase/response regulator -
FOB25_RS09410 1984342..1985865 + 1524 WP_003844755.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11860.49 Da        Isoelectric Point: 9.9581

>T140056 WP_032942116.1 NZ_CP044098:c1981408-1981106 [Citrobacter portucalensis]
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

>T140056 NZ_CP058886:183506-183613 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.83 Da        Isoelectric Point: 6.4743

>AT140056 WP_008786950.1 NZ_CP044098:c1981085-1980744 [Citrobacter portucalensis]
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA

Download         Length: 342 bp

>AT140056 NZ_CP058886:c183458-183392 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BY49

References