140038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 936993..937506 Replicon chromosome
Accession NZ_CP044091
Organism Streptococcus agalactiae strain FDAARGOS_669

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag FOB77_RS05165 Protein ID WP_000481712.1
Coordinates 937252..937506 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag FOB77_RS05160 Protein ID WP_000387490.1
Coordinates 936993..937259 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB77_RS05125 933240..934472 + 1233 WP_000338839.1 replication initiation factor domain-containing protein -
FOB77_RS05130 934488..934865 + 378 WP_000287185.1 hypothetical protein -
FOB77_RS05135 934852..935082 + 231 WP_001866982.1 helix-turn-helix domain-containing protein -
FOB77_RS05140 935075..935428 + 354 WP_000571928.1 helix-turn-helix domain-containing protein -
FOB77_RS05145 935560..935832 + 273 WP_000072643.1 hypothetical protein -
FOB77_RS05150 935885..936367 + 483 WP_000383283.1 antirestriction protein ArdA -
FOB77_RS05155 936375..936848 + 474 WP_000560386.1 hypothetical protein -
FOB77_RS05160 936993..937259 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOB77_RS05165 937252..937506 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
FOB77_RS05170 937559..938512 + 954 WP_000565541.1 conjugal transfer protein -
FOB77_RS05175 938533..938799 + 267 WP_001055037.1 hypothetical protein -
FOB77_RS05180 938803..939213 + 411 WP_000390749.1 conjugal transfer protein -
FOB77_RS05185 939234..941735 + 2502 WP_000239404.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 927039..952673 25634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T140038 WP_000481712.1 NZ_CP044091:937252-937506 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T140038 NZ_CP058879:c2134392-2134285 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT140038 WP_000387490.1 NZ_CP044091:936993-937259 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT140038 NZ_CP058879:2134445-2134506 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References