Detailed information of TA system TA140032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4874944..4875599
• Replicon: chromosome
• Accession: NZ_CP044089
• Organism: Bordetella bronchiseptica strain FDAARGOS_634

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOB42_RS22920
• Protein ID: WP_050461266.1
• Coordinates: 4875348..4875599 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: FOB42_RS22915
• Protein ID: WP_003819831.1
• Coordinates: 4874944..4875345 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB42_RS22885	4870128..4871150	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
FOB42_RS22890	4871287..4872324	-	1038	WP_033459991.1	threonylcarbamoyl-AMP synthase	-
FOB42_RS22895	4872344..4873534	-	1191	WP_015041223.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FOB42_RS22900	4873537..4874052	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FOB42_RS22905	4874201..4874680	-	480	WP_003819836.1	disulfide bond formation protein B	-
FOB42_RS22910	4874688..4874924	-	237	WP_003819834.1	hypothetical protein	-
FOB42_RS22915	4874944..4875345	-	402	WP_003819831.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOB42_RS22920	4875348..4875599	-	252	WP_050461266.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOB42_RS22925	4875654..4876535	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
FOB42_RS22930	4876761..4877207	+	447	WP_003819827.1	GFA family protein	-
FOB42_RS22935	4877292..4878356	-	1065	WP_003819826.1	fructose-bisphosphate aldolase class II	-
FOB42_RS22940	4878532..4879074	-	543	WP_125327321.1	MOSC domain-containing protein	-
FOB42_RS22945	4879309..4880439	+	1131	WP_003819823.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8926.43 Da
• Isoelectric Point: 9.7242

>T140032 WP_050461266.1 NZ_CP044089:c4875599-4875348 [Bordetella bronchiseptica]
IGGAATKKPGQKRRAGAAALGLDFSAMVETVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPVVSF
KEL

Nucleotide

• Length: 252 bp

>T140032 NZ_CP058879:789708-790004 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14559.72 Da
• Isoelectric Point: 8.5005

>AT140032 WP_003819831.1 NZ_CP044089:c4875345-4874944 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCQACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT140032 NZ_CP058879:790006-790401 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA