Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3880521..3881195 Replicon chromosome
Accession NZ_CP044074
Organism Pseudomonas oryzihabitans strain FDAARGOS_657

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOB65_RS19425 Protein ID WP_144945649.1
Coordinates 3880917..3881195 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOB65_RS19420 Protein ID WP_027598623.1
Coordinates 3880521..3880823 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB65_RS19400 3875891..3876829 + 939 WP_027600430.1 choline ABC transporter substrate-binding protein -
FOB65_RS19405 3877100..3878038 + 939 WP_027598620.1 choline ABC transporter substrate-binding protein -
FOB65_RS19410 3878155..3878997 + 843 WP_027598621.1 choline ABC transporter permease subunit -
FOB65_RS19415 3879001..3880233 + 1233 WP_150340202.1 choline ABC transporter ATP-binding protein -
FOB65_RS19420 3880521..3880823 - 303 WP_027598623.1 HigA family addiction module antidote protein Antitoxin
FOB65_RS19425 3880917..3881195 - 279 WP_144945649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB65_RS19430 3881450..3882307 - 858 WP_077171181.1 formyltetrahydrofolate deformylase -
FOB65_RS19435 3882406..3883035 - 630 WP_007160039.1 sarcosine oxidase subunit gamma family protein -
FOB65_RS19440 3883051..3886071 - 3021 WP_027598627.1 sarcosine oxidase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10650.12 Da        Isoelectric Point: 9.2972

>T140003 WP_144945649.1 NZ_CP044074:c3881195-3880917 [Pseudomonas oryzihabitans]
MILSFKCKDTQALFTDGNNRKWSQIANVATRRLTALSEAVELRDLRSPPGNRLELLEGKRKGQHSIRINDQWRICFEWTP
QGPANVEIVDYH

Download         Length: 279 bp

>T140003 NZ_CP058874:354462-354737 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10988.78 Da        Isoelectric Point: 7.2024

>AT140003 WP_027598623.1 NZ_CP044074:c3880823-3880521 [Pseudomonas oryzihabitans]
MLTNGMRPVHPGEILREDYLVPMNMTPSALARALGVSAPTVNDVVLERRGISADMALRLAAAFDTTPNFWMGLQATYELR
VAETSKGELIRQQVKPLHVA

Download         Length: 303 bp

>AT140003 NZ_CP058874:354734-355093 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References