Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 387088..387920 Replicon chromosome
Accession NZ_CP044065
Organism Cupriavidus pauculus strain FDAARGOS_664

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag FOB72_RS01800 Protein ID WP_150370966.1
Coordinates 387414..387920 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag FOB72_RS01795 Protein ID WP_150370965.1
Coordinates 387088..387417 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB72_RS01765 382533..382922 - 390 Protein_346 hypothetical protein -
FOB72_RS01770 383254..384069 + 816 WP_150370961.1 peptidoglycan-binding protein -
FOB72_RS01775 384193..384543 + 351 WP_150373706.1 cytochrome c family protein -
FOB72_RS01780 384582..385475 - 894 WP_150370962.1 SDR family oxidoreductase -
FOB72_RS01785 385518..385958 - 441 WP_150370963.1 hypothetical protein -
FOB72_RS01790 386093..386983 + 891 WP_150370964.1 LysR family transcriptional regulator -
FOB72_RS01795 387088..387417 + 330 WP_150370965.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
FOB72_RS01800 387414..387920 + 507 WP_150370966.1 type II toxin-antitoxin system YhaV family toxin Toxin
FOB72_RS01810 388479..389141 - 663 WP_150370967.1 phosphoglycolate phosphatase -
FOB72_RS01815 389147..389887 - 741 WP_150370968.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
FOB72_RS01820 389967..390626 - 660 WP_109580381.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 19275.80 Da        Isoelectric Point: 9.7457

>T139982 WP_150370966.1 NZ_CP044065:387414-387920 [Cupriavidus pauculus]
MKQGSSTAFVVHGWTVYAHPLFVAQIEALAKHVDSLKRKDPTGYVKKNATKRLAAVTALAFDIIPQDPTRAEYRQGGTLG
AERKHWFRAKFFQQYRLFFRYHAASRIIVFAWVNDDDTKRAYESSDDAYRVFRKMLESGHPPDDWDQLLSEACSGGHRLQ
EIDAAIRN

Download         Length: 507 bp

>T139982 NZ_CP058866:c5242010-5241627 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12005.45 Da        Isoelectric Point: 4.5034

>AT139982 WP_150370965.1 NZ_CP044065:387088-387417 [Cupriavidus pauculus]
MPATIEVESTLTDRYQTTVPETVRRALGLGKRDKIHYSIRASGEVVLTRAEASEGEDPVLEQFLSFLERDIASHPQRVRP
VDAAFVARLQSLAGGVKVDLDAPLSEDDE

Download         Length: 330 bp

>AT139982 NZ_CP058866:c5242252-5242010 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References