Detailed information of TA system TA139980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3062841..3063535
• Replicon: chromosome
• Accession: NZ_CP044064
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_665

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOB73_RS14055
• Protein ID: WP_024063131.1
• Coordinates: 3063239..3063535 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: FOB73_RS14050
• Protein ID: WP_002209924.1
• Coordinates: 3062841..3063239 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB73_RS14025	3058132..3058497	+	366	WP_002209919.1	hypothetical protein	-
FOB73_RS20225	3058510..3058743	+	234	Protein_2626	hypothetical protein	-
FOB73_RS20230	3058858..3059177	+	320	Protein_2627	hypothetical protein	-
FOB73_RS14035	3059359..3059559	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
FOB73_RS20235	3059573..3059725	-	153	WP_002209921.1	hypothetical protein	-
FOB73_RS14040	3059718..3060044	-	327	WP_038824361.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FOB73_RS14045	3060344..3062450	+	2107	Protein_2631	DNA primase	-
FOB73_RS14050	3062841..3063239	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOB73_RS14055	3063239..3063535	-	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOB73_RS14060	3063699..3064061	-	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
FOB73_RS14065	3064124..3064392	-	269	Protein_2635	type II toxin-antitoxin system RelE/ParE family toxin	-
FOB73_RS14070	3064990..3065175	+	186	WP_002209928.1	hypothetical protein	-
FOB73_RS14075	3065257..3066471	-	1215	WP_011192954.1	tyrosine-type recombinase/integrase	-
FOB73_RS14085	3066904..3068421	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T139980 WP_024063131.1 NZ_CP044064:c3063535-3063239 [Yersinia pseudotuberculosis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T139980 NZ_CP044064:c3063535-3063239 [Yersinia pseudotuberculosis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT139980 WP_002209924.1 NZ_CP044064:c3063239-3062841 [Yersinia pseudotuberculosis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT139980 NZ_CP044064:c3063239-3062841 [Yersinia pseudotuberculosis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1