Detailed information of TA system TA139959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 441878..442577
• Replicon: chromosome
• Accession: NZ_CP044056
• Organism: Burkholderia multivorans strain FDAARGOS_622

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOB30_RS02020
• Protein ID: WP_053298526.1
• Coordinates: 441878..442174 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: FOB30_RS02025
• Protein ID: WP_006403504.1
• Coordinates: 442176..442577 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB30_RS02005	438603..440144	+	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-
FOB30_RS02010	440351..440623	+	273	WP_006403506.1	hypothetical protein	-
FOB30_RS02015	440724..441758	+	1035	WP_053298527.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
FOB30_RS02020	441878..442174	+	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOB30_RS02025	442176..442577	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOB30_RS02030	442866..443426	+	561	WP_053298525.1	GNAT family N-acetyltransferase	-
FOB30_RS02035	443492..444433	+	942	WP_035487669.1	ABC transporter substrate-binding protein	-
FOB30_RS02040	444465..445526	+	1062	WP_150331523.1	LLM class flavin-dependent oxidoreductase	-
FOB30_RS02045	445523..446875	+	1353	WP_053298523.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T139959 WP_053298526.1 NZ_CP044056:441878-442174 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T139959 NZ_CP058858:c36468-36052 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT139959 WP_006403504.1 NZ_CP044056:442176-442577 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT139959 NZ_CP058858:c36695-36465 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: B9BI88