Detailed information of TA system TA139954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1811120..1811819
• Replicon: chromosome
• Accession: NZ_CP044055
• Organism: Burkholderia multivorans strain FDAARGOS_623

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: FOB31_RS28575
• Protein ID: WP_053298526.1
• Coordinates: 1811523..1811819 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: FOB31_RS28570
• Protein ID: WP_006403504.1
• Coordinates: 1811120..1811521 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB31_RS28550	1806822..1808174	-	1353	WP_053298523.1	LLM class flavin-dependent oxidoreductase	-
FOB31_RS28555	1808171..1809232	-	1062	WP_150331523.1	LLM class flavin-dependent oxidoreductase	-
FOB31_RS28560	1809264..1810205	-	942	WP_035487669.1	ABC transporter substrate-binding protein	-
FOB31_RS28565	1810271..1810831	-	561	WP_053298525.1	GNAT family N-acetyltransferase	-
FOB31_RS28570	1811120..1811521	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOB31_RS28575	1811523..1811819	-	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOB31_RS28580	1811939..1812973	-	1035	WP_053298527.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
FOB31_RS28585	1813074..1813346	-	273	WP_006403506.1	hypothetical protein	-
FOB31_RS28590	1813553..1815094	-	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T139954 WP_053298526.1 NZ_CP044055:c1811819-1811523 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T139954 NZ_CP058857:c4772245-4771712 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT139954 WP_006403504.1 NZ_CP044055:c1811521-1811120 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT139954 NZ_CP058857:c4772522-4772256 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: B9BI88