Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 803746..804343 Replicon chromosome
Accession NZ_CP044047
Organism Klebsiella pneumoniae strain FDAARGOS_629

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag FOB37_RS05920 Protein ID WP_004142563.1
Coordinates 803746..804063 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag FOB37_RS05925 Protein ID WP_004142561.1
Coordinates 804056..804343 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB37_RS05905 799446..800873 - 1428 WP_009308097.1 MFS transporter -
FOB37_RS05910 800982..801848 + 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
FOB37_RS05915 802518..803561 + 1044 WP_040153598.1 DUF2157 domain-containing protein -
FOB37_RS05920 803746..804063 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB37_RS05925 804056..804343 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
FOB37_RS05930 804608..805246 - 639 WP_064277739.1 oxygen-insensitive NAD(P)H nitroreductase -
FOB37_RS05935 805366..805734 - 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
FOB37_RS05940 805731..806315 - 585 WP_071579668.1 TetR/AcrR family transcriptional regulator -
FOB37_RS05945 806495..807610 + 1116 WP_012737592.1 MBL fold metallo-hydrolase -
FOB37_RS05950 807641..807982 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
FOB37_RS05955 808000..808248 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T139934 WP_004142563.1 NZ_CP044047:803746-804063 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T139934 NZ_CP058853:c3424245-3423910 [Shigella flexneri]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT139934 WP_004142561.1 NZ_CP044047:804056-804343 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT139934 NZ_CP058853:c3424493-3424245 [Shigella flexneri]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References