Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4229471..4230117 Replicon chromosome
Accession NZ_CP044039
Organism Klebsiella pneumoniae strain FDAARGOS_630

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag FOB38_RS22680 Protein ID WP_032433636.1
Coordinates 4229471..4229818 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag FOB38_RS22685 Protein ID WP_019725405.1
Coordinates 4229818..4230117 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB38_RS22670 4225397..4226830 + 1434 WP_032433640.1 glycogen synthase GlgA -
FOB38_RS22675 4226848..4229295 + 2448 WP_032433638.1 glycogen phosphorylase -
FOB38_RS22680 4229471..4229818 + 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB38_RS22685 4229818..4230117 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
FOB38_RS22690 4230180..4231688 - 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
FOB38_RS22695 4231893..4232222 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
FOB38_RS22700 4232273..4233103 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
FOB38_RS22705 4233153..4233911 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T139927 WP_032433636.1 NZ_CP044039:4229471-4229818 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T139927 NZ_CP058853:c1774543-1774436 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT139927 WP_019725405.1 NZ_CP044039:4229818-4230117 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT139927 NZ_CP058853:1774590-1774656 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References